Home > Cruises > Central America Cruises > Panama > Cruises From Colon

Cruises From Colon

Choose from 21 unique cruises starting in Colon, and travelling to Cancun, Cartagena, Fort-de-France, Los Angeles and Puntarenas. January is the most popular month to join a cruise from Colon and you can select from 38 departures available from three leading cruise lines.
Filter Results
Departures
Duration
2 Days
13 Days
End City
Ship Features
Operators
Price
$100pp
$32,930pp
Countries
Show More...
Filter Results
21 Cruises (38 Cruise Departures)
11 Day Secrets of Central America with Ponant
Cruise

11 Days (10 Nights) Colon to Puntarenas
Cruise Line: Ponant
Ship: Le Bellot
Departure: 23 February 2025
Countries Visited: Panama, Costa Rica
Exclusive Savings
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$32,286
Save (per person) 644
From (per person) 32,286
View Trip
9 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

9 Days (8 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 12 December 2025
Countries Visited: Panama, Colombia, Bonaire, Aruba (+1 more), Curacao
Exclusive Deal
INSIDE
$1,799
OCEANVIEW
$1,867
BALCONY
$1,947
SUITE
$2,332
Save (per person) 1,011
From (per person) 1,799
View Trip
11 Day A Tropical Odyssey in Central America with Ponant
Cruise

11 Days (10 Nights) Colon to Cancun
Cruise Line: Ponant
Ship: Le Champlain
Departure: 03 December 2025
Countries Visited: Panama, Costa Rica, Colombia, Honduras (+3 more), Guatemala, Belize, Mexico
Exclusive Savings
INSIDE
-
OCEANVIEW
-
BALCONY
$11,103
SUITE
$17,051
Save (per person) 207
From (per person) 11,103
View Trip
2 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

2 Days (1 Nights) Colon to Cartagena
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 18 April 2026
Countries Visited: Panama, Colombia
Exclusive DealLatest Offer
INSIDE
$170
OCEANVIEW
$229
BALCONY
$240
SUITE
$353
Save (per person) 195
From (per person) 170
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Nov 2025 to Nov 2025
Countries Visited: Panama, Colombia, Bonaire, Curacao
Exclusive Deal
INSIDE
$1,405
OCEANVIEW
$1,404
BALCONY
$1,370
SUITE
$2,047
Save (per person) 935
From (per person) 1,370
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Oct 2025 to Apr 2026
Countries Visited: Panama, Colombia, Curacao, Aruba
Exclusive Deal
INSIDE
$1,251
OCEANVIEW
$1,394
BALCONY
$1,534
SUITE
$1,974
Save (per person) 1,010
From (per person) 1,251
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Jan 2026 to Feb 2026
Countries Visited: Panama, Colombia, Bonaire, Aruba
Exclusive Deal
INSIDE
$1,248
OCEANVIEW
$1,283
BALCONY
$1,493
SUITE
$2,320
Save (per person) 831
From (per person) 1,248
View Trip
11 Day Panama Canal Westward Cruise with Royal Caribbean
Cruise

11 Days (10 Nights) Colon to Los Angeles
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 25 April 2026
Countries Visited: Panama, Costa Rica, Mexico, USA
Exclusive DealExclusive Solo Offer
INSIDE
$2,033
OCEANVIEW
$2,507
BALCONY
$3,079
SUITE
$4,380
Save (per person) 913
From (per person) 2,033
View Trip
8 Day Southern Caribbean Holiday with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 20 December 2025
Countries Visited: Panama, Colombia, Curacao, Aruba
Exclusive Deal
INSIDE
$1,671
OCEANVIEW
$1,729
BALCONY
$1,890
SUITE
$2,696
Save (per person) 966
From (per person) 1,671
View Trip
13 Day Pacific Pathways with Oceania Cruises
Cruise

13 Days (12 Nights) Colon to Los Angeles
Cruise Line: Oceania Cruises
Ship: Oceania Regatta
Departure: 14 November 2025
Countries Visited: Panama, Costa Rica, Nicaragua, Guatemala (+2 more), Mexico, USA
Mutiple Deals Available
INSIDE
$3,081
OCEANVIEW
$3,457
BALCONY
$5,025
SUITE
$7,051
Save (per person) 4,539
From (per person) 3,081
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 28 March 2026
Countries Visited: Panama, Colombia, Aruba, Bonaire
Exclusive Deal
INSIDE
$1,665
OCEANVIEW
$1,816
BALCONY
$2,076
SUITE
$2,901
Save (per person) 960
From (per person) 1,665
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Oct 2025 to Nov 2025
Countries Visited: Panama, Colombia, Aruba, Curacao
Exclusive Deal
INSIDE
$1,409
OCEANVIEW
$1,409
BALCONY
$1,383
SUITE
$1,974
Save (per person) 1,042
From (per person) 1,383
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Jan 2026 to Mar 2026
Countries Visited: Panama, Colombia, Aruba, Curacao
Exclusive Deal
INSIDE
$1,252
OCEANVIEW
$1,402
BALCONY
$1,662
SUITE
$2,356
Save (per person) 907
From (per person) 1,252
View Trip
7 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

7 Days (6 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 06 December 2025
Countries Visited: Panama, Colombia, Aruba, Curacao
Exclusive Deal
INSIDE
$1,360
OCEANVIEW
$1,399
BALCONY
$1,582
SUITE
$2,251
Save (per person) 817
From (per person) 1,360
View Trip
8 Day Panama and Costa Rica by Sea: The Natural Wonders of Central America – with Smithsonian Journeys with Ponant
Cruise

8 Days (7 Nights) Colon to Puntarenas
Cruise Line: Ponant
Ship: Le Champlain
Departure: 19 February 2026
Countries Visited: Panama, Costa Rica
Exclusive Savings
INSIDE
-
OCEANVIEW
-
BALCONY
$8,174
SUITE
$13,779
Save (per person) 156
From (per person) 8,174
View Trip
13 Day Panama, Colombia & Caribbean Islands with Ponant
Cruise

13 Days (12 Nights) Colon to Fort-de-France
Cruise Line: Ponant
Ship: Le Dumont d’Urville
Departure: 16 January 2026
Countries Visited: Panama, Colombia, Curacao, Saint Vincent (+3 more), Saint Lucia, Guadeloupe, Martinique
Exclusive Savings
INSIDE
-
OCEANVIEW
-
BALCONY
$9,573
SUITE
$15,325
Save (per person) 177
From (per person) 9,573
View Trip
11 Day Secrets of Central America with Ponant
Cruise

11 Days (10 Nights) Colon to Puntarenas
Cruise Line: Ponant
Ship: Le Champlain
Departures: Jan 2026 to Mar 2026
Countries Visited: Panama, Costa Rica
Exclusive Savings
INSIDE
-
OCEANVIEW
-
BALCONY
$12,402
SUITE
$19,174
Save (per person) 280
From (per person) 12,402
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Dec 2025 to Feb 2026
Countries Visited: Panama, Colombia, Aruba, Bonaire
Exclusive Deal
INSIDE
$1,224
OCEANVIEW
$1,285
BALCONY
$1,448
SUITE
$2,245
Save (per person) 1,077
From (per person) 1,224
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 17 January 2026
Countries Visited: Panama, Colombia, Bonaire, Aruba
Exclusive Deal
INSIDE
$1,648
OCEANVIEW
$1,686
BALCONY
$1,718
SUITE
$2,292
Save (per person) 950
From (per person) 1,648
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Nov 2025 to Apr 2026
Countries Visited: Panama, Colombia, Aruba, Curacao
Exclusive Deal
INSIDE
$1,251
OCEANVIEW
$1,394
BALCONY
$1,380
SUITE
$2,268
Save (per person) 935
From (per person) 1,251
View Trip
8 Day Central America Jewels & Panama Canal with Ponant
Cruise

8 Days (7 Nights) Colon to Puntarenas
Cruise Line: Ponant
Ship: Le Dumont d’Urville
Departures: Dec 2025 to Jan 2026
Countries Visited: Panama, Costa Rica
Exclusive Savings
INSIDE
-
OCEANVIEW
-
BALCONY
$6,959
SUITE
$11,908
Save (per person) 147
From (per person) 6,959
View Trip
Results: 21 results

No Results found. Try changing your search filters.




Cruises found! Scroll up to view

South & Central America Cruises

Central America Cruises South America Cruises Mexico Cruises Galapagos Cruises Bermunda Cruises Bahamas Cruises Caribbean Cruises Amazon Cruises Patagonia Cruises Cape Horn Cruises Falkland Island Cruises Panama Cruises

Travel Styles

Luxury Cruises

Departure Months

February 2025 October 2025 November 2025 December 2025 January 2026 February 2026 March 2026 April 2026

Cities

Colon Panama City Santiago

Routes

Colon to Colon Miami to Panama City Panama City to Miami

Country Routes

Panama to USA USA to Panama

Cruise Lines Exploring South & Central America

Azamara South America Cruises Celebrity Central America Cruises Cunard Central America Cruises HX Hurtigruten South America Expeditions MSC South America Cruises NCL Central America Cruises Oceania South America Cruises Ponant Central America Cruises Ponant South America Cruises Princess South America Cruises Regent Seven Seas South America Cruises Royal Caribbean Central America Cruises Seabourn South America Cruises Silversea South America Cruises Viking South America Cruises Viking Central America Cruises

Central America Tours

All Central America Tours Belize Tours Costa Rica Tours Guatemala Tours Mexico Tours Panama Tours

© 2010-2025. Global Journeys. You're viewing our site in Australian dollars.

    

About Us | View Your Booking | Terms & Conditions | Site Map

Global Journeys Pty Ltd. Accredited Member of The Australian Travel Industry Association (AITA). No. A11351.

Travel Industry Associations