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Cruises Starting and Ending in Colon

Are you looking for a cruise starting and ending in Colon? December, January and March are the most popular months to join a roundtrip cruise from Colon and we have 27 departures available from one of the world's leading cruise lines.
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9 Days
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$1,200pp
$2,989pp
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12 Cruises (27 Cruise Departures)
9 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

9 Days (8 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 12 December 2025
Countries Visited: Panama, Colombia, Bonaire, Aruba (+1 more), Curacao
Exclusive Deal
INSIDE
$1,799
OCEANVIEW
$1,867
BALCONY
$1,947
SUITE
$2,332
Save (per person) 1,011
From (per person) 1,799
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Nov 2025 to Nov 2025
Countries Visited: Panama, Colombia, Bonaire, Curacao
Exclusive Deal
INSIDE
$1,405
OCEANVIEW
$1,404
BALCONY
$1,370
SUITE
$2,047
Save (per person) 935
From (per person) 1,370
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Oct 2025 to Apr 2026
Countries Visited: Panama, Colombia, Curacao, Aruba
Exclusive Deal
INSIDE
$1,251
OCEANVIEW
$1,394
BALCONY
$1,534
SUITE
$1,974
Save (per person) 1,010
From (per person) 1,251
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Jan 2026 to Feb 2026
Countries Visited: Panama, Colombia, Bonaire, Aruba
Exclusive Deal
INSIDE
$1,248
OCEANVIEW
$1,283
BALCONY
$1,493
SUITE
$2,320
Save (per person) 831
From (per person) 1,248
View Trip
8 Day Southern Caribbean Holiday with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 20 December 2025
Countries Visited: Panama, Colombia, Curacao, Aruba
Exclusive Deal
INSIDE
$1,671
OCEANVIEW
$1,729
BALCONY
$1,890
SUITE
$2,696
Save (per person) 966
From (per person) 1,671
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 28 March 2026
Countries Visited: Panama, Colombia, Aruba, Bonaire
Exclusive Deal
INSIDE
$1,665
OCEANVIEW
$1,816
BALCONY
$2,076
SUITE
$2,901
Save (per person) 960
From (per person) 1,665
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Oct 2025 to Nov 2025
Countries Visited: Panama, Colombia, Aruba, Curacao
Exclusive Deal
INSIDE
$1,409
OCEANVIEW
$1,409
BALCONY
$1,383
SUITE
$1,974
Save (per person) 1,042
From (per person) 1,383
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Jan 2026 to Mar 2026
Countries Visited: Panama, Colombia, Aruba, Curacao
Exclusive Deal
INSIDE
$1,252
OCEANVIEW
$1,402
BALCONY
$1,662
SUITE
$2,356
Save (per person) 907
From (per person) 1,252
View Trip
7 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

7 Days (6 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 06 December 2025
Countries Visited: Panama, Colombia, Aruba, Curacao
Exclusive Deal
INSIDE
$1,360
OCEANVIEW
$1,399
BALCONY
$1,582
SUITE
$2,251
Save (per person) 817
From (per person) 1,360
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Dec 2025 to Feb 2026
Countries Visited: Panama, Colombia, Aruba, Bonaire
Exclusive Deal
INSIDE
$1,224
OCEANVIEW
$1,285
BALCONY
$1,448
SUITE
$2,245
Save (per person) 1,077
From (per person) 1,224
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 17 January 2026
Countries Visited: Panama, Colombia, Bonaire, Aruba
Exclusive Deal
INSIDE
$1,648
OCEANVIEW
$1,686
BALCONY
$1,718
SUITE
$2,292
Save (per person) 950
From (per person) 1,648
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Nov 2025 to Apr 2026
Countries Visited: Panama, Colombia, Aruba, Curacao
Exclusive Deal
INSIDE
$1,251
OCEANVIEW
$1,394
BALCONY
$1,380
SUITE
$2,268
Save (per person) 935
From (per person) 1,251
View Trip
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