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Cruises from Rome to Istanbul

Are you looking for a cruise from Rome to Istanbul? September is the most popular month to cruise between Rome and Istanbul and there are 39 departures available from four of the world's leading cruise lines.
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8 Days
22 Days
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$1,900pp
$39,995pp
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11 Cruises (39 Cruise Departures)
22 Day Adriatic & Mediterranean Sojourn with Viking Cruises
Cruise
 (7)

22 Days (21 Nights) Rome to Istanbul
Operated By: Viking Cruises
Ships: Viking Jupiter, Viking Mars (+6 more), Viking Neptune, Viking Saturn, Viking Sea, Viking Sky, Viking Star, Viking Vesta
Departures: Apr 2025 to Jul 2027
Countries Visited: Italy, Sicily, Croatia, Montenegro (+2 more), Greece, Turkey
Companion Fly Free
INSIDE
-
OCEANVIEW
-
BALCONY
$17,733
SUITE
$23,711
Save (per person) 800
From (per person) 17,733
View Trip
12 Day Eastern Mediterranean From Rome To Istanbul with Norwegian Cruise Line
Cruise
 (1)

12 Days (11 Nights) Rome to Istanbul
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Viva
Departure: 07 May 2025
Countries Visited: Italy, Sicily, Egypt, Cyprus (+2 more), Greece, Turkey
NCL's More at Sea
INSIDE
$3,852
OCEANVIEW
$5,352
BALCONY
$4,310
SUITE
$5,687
From (per person) 3,852
View Trip
10 Day Greek Isles & Italy with Norwegian Cruise Line
Cruise
 (1)

10 Days (9 Nights) Rome to Istanbul
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Viva
Departures: May 2026 to Jul 2026
Countries Visited: Italy, Sicily, Malta, Greece (+1 more), Turkey
NCL's More at Sea
INSIDE
$4,442
OCEANVIEW
$4,963
BALCONY
$5,773
SUITE
$7,074
From (per person) 4,442
View Trip
8 Day Hellenic & Dalmatian Gems with Oceania Cruises
Cruise
 (1)

8 Days (7 Nights) Rome to Istanbul
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 05 November 2026
Countries Visited: Italy, Sicily, Malta, Greece (+1 more), Turkey
Exclusive Deal
INSIDE
$3,169
OCEANVIEW
$3,476
BALCONY
$5,129
SUITE
$7,079
Save (per person) 2,021
From (per person) 3,169
View Trip
13 Day Artifacts & Antiquities with Oceania Cruises
Cruise

13 Days (12 Nights) Rome to Istanbul
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 14 September 2026
Countries Visited: Italy, Sardinia, Sicily, Malta (+2 more), Greece, Turkey
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$8,292
SUITE
$13,401
Save (per person) 2,068
From (per person) 8,292
View Trip
12 Day Antiquity To Anatolia with Oceania Cruises
Cruise

12 Days (11 Nights) Rome to Istanbul
Cruise Line: Oceania Cruises
Ship: Oceania Vista
Departure: 29 October 2025
Countries Visited: Italy, Sicily, Greece, Turkey
Exclusive DealFlash Sale + Bonus Onboard Credit
INSIDE
-
OCEANVIEW
-
BALCONY
$5,431
SUITE
$8,433
Save (per person) 3,409
From (per person) 5,431
View Trip
8 Day Istanbul, Greek Isles And Italy with Cunard
Cruise

8 Days (7 Nights) Rome to Istanbul
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 21 September 2026
Countries Visited: Italy, Greece, Turkey
Exclusive Deal
INSIDE
$1,981
OCEANVIEW
$2,130
BALCONY
$2,526
SUITE
$5,199
From (per person) 1,981
View Trip
13 Day Italy & Ancient Isles with Oceania Cruises
Cruise

13 Days (12 Nights) Rome to Istanbul
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 04 October 2025
Countries Visited: Italy, Sicily, Malta, Greece (+1 more), Turkey
Mutiple Deals Available
INSIDE
$4,540
OCEANVIEW
$5,385
BALCONY
$6,224
SUITE
$8,538
Save (per person) 3,990
From (per person) 4,540
View Trip
8 Day Greece And Turkey with Cunard
Cruise

8 Days (7 Nights) Rome to Istanbul
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 12 May 2025
Countries Visited: Italy, Greece, Turkey
Exclusive Deal
INSIDE
$1,932
OCEANVIEW
$2,110
BALCONY
$2,427
SUITE
$4,506
From (per person) 1,932
View Trip
15 Day Istanbul, Greek Islands And Mediterranean with Cunard
Cruise

15 Days (14 Nights) Rome to Istanbul
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 14 September 2026
Countries Visited: Italy, France, Greece, Turkey
Exclusive Deal
INSIDE
$4,112
OCEANVIEW
$4,657
BALCONY
$5,291
SUITE
$10,795
From (per person) 4,112
View Trip
15 Day Ancient Mediterranean Antiquities with Viking Cruises
Cruise

15 Days (14 Nights) Rome to Istanbul
Operated By: Viking Cruises
Ships: Viking Jupiter, Viking Mira (+5 more), Viking Neptune, Viking Saturn, Viking Star, Viking Vela, Viking Vesta
Departures: Dec 2025 to Feb 2027
Countries Visited: Italy, Sicily, Greece, Turkey
Companion Fly Free
INSIDE
-
OCEANVIEW
-
BALCONY
$10,775
SUITE
$15,675
Save (per person) 310
From (per person) 10,775
View Trip
Results: 11 results

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