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Cruises from Italy to Spain

Are you looking for a cruise from Italy to Spain? October is the most popular month to cruise between Italy and Spain and there are 294 departures available from fifteen of the world's leading cruise lines.
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140 Cruises (294 Cruise Departures)
13 Day Mediterranean Odyssey with Viking Cruises
Cruise
 (6)

13 Days (12 Nights) Venice to Barcelona
Operated By: Viking Cruises
Ships: Viking Jupiter, Viking Mars (+5 more), Viking Saturn, Viking Sea, Viking Sky, Viking Star, Viking Vesta
Departures: Jun 2025 to Aug 2027
Countries Visited: Italy, Croatia, Greece, Monaco (+2 more), France, Spain
Companion Fly Free
INSIDE
-
OCEANVIEW
-
BALCONY
$8,521
SUITE
$11,461
Save (per person) 448
From (per person) 8,521
View Trip
10 Day Italian Riviera & France with Celebrity Cruises
Cruise

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departures: May 2025 to Sep 2026
Countries Visited: Italy, France, Spain
Endless Summer Sale
INSIDE
$2,104
OCEANVIEW
$2,101
BALCONY
$2,110
SUITE
$7,421
Save (per person) 1,622
From (per person) 2,101
View Trip
8 Day Iconic Western Mediterranean with Viking Cruises
Cruise
 (5)

8 Days (7 Nights) Rome to Barcelona
Operated By: Viking Cruises
Ships: Viking Jupiter, Viking Mars (+8 more), Viking Mira, Viking Neptune, Viking Saturn, Viking Sea, Viking Sky, Viking Star, Viking Vela, Viking Vesta
Departures: Jul 2025 to Sep 2027
Countries Visited: Italy, Monaco, France, Spain
Companion Fly Free
INSIDE
-
OCEANVIEW
-
BALCONY
$5,287
SUITE
$7,247
Save (per person) 194
From (per person) 5,287
View Trip
11 Day Italy, Greece, & France: Mediterranean Jewels with Norwegian Cruise Line
Cruise
 (1)

11 Days (10 Nights) Venice to Barcelona
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Breakaway
Departures: May 2025 to Oct 2025
Countries Visited: Italy, Croatia, Greece, Sicily (+2 more), France, Spain
NCL's More at SeaExclusive Solo Offer
INSIDE
$3,103
OCEANVIEW
$3,867
BALCONY
$4,862
SUITE
$5,474
From (per person) 3,103
View Trip
8 Day Western Mediterranean Cruise: Italy, France & Spain with Azamara Cruises
Cruise
 (3)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 31 October 2026
Countries Visited: Italy, Monaco, France, Spain
INSIDE
$2,917
OCEANVIEW
$3,451
BALCONY
$4,006
SUITE
$5,520
From (per person) 2,917
View Trip
11 Day Italy & France Spotlight with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 22 May 2026
Countries Visited: Italy, Sicily, Sardinia, Corsica (+2 more), France, Spain
Exclusive Deal
INSIDE
$4,584
OCEANVIEW
$5,083
BALCONY
$7,584
SUITE
$10,443
Save (per person) 2,276
From (per person) 4,584
View Trip
8 Day Mediterranean Holiday Cruise: Barcelona, Palma & Florence with Azamara Cruises
Cruise
 (3)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 22 December 2026
Countries Visited: Italy, Spain
INSIDE
$2,384
OCEANVIEW
$2,750
BALCONY
$3,552
SUITE
$5,621
From (per person) 2,384
View Trip
15 Day Mediterranean with Greek Isles, Italy & Turkey with Princess
Cruise
 (2)

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Princess
Ship: Sun Princess
Departure: 06 September 2025
Countries Visited: Italy, Greece, Turkey, Montenegro (+2 more), Sicily, Spain
Exclusive Deal
INSIDE
$6,087
OCEANVIEW
$6,998
BALCONY
$7,433
SUITE
$8,186
From (per person) 6,087
View Trip
8 Day Essential Mediterranean with Oceania Cruises
Cruise
 (3)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 09 June 2026
Countries Visited: Italy, Monaco, France, Spain
Exclusive Deal
INSIDE
$3,152
OCEANVIEW
$3,444
BALCONY
$5,156
SUITE
$7,159
Save (per person) 2,188
From (per person) 3,152
View Trip
11 Day Autumnal Mediterranean with Oceania Cruises
Cruise
 (3)

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 18 October 2025
Countries Visited: Italy, Sicily, Malta, Tunisia (+3 more), Monaco, France, Spain
Your World + Bonus Shipboard CreditExclusive Deal
INSIDE
$4,076
OCEANVIEW
$4,343
BALCONY
$6,642
SUITE
$9,350
Save (per person) 2,484
From (per person) 4,076
View Trip
8 Day Italy & France Cruise with Royal Caribbean
Cruise
 (2)

8 Days (7 Nights) Bologna to Barcelona
Cruise Line: Royal Caribbean
Ship: Brilliance of the Seas
Departure: 26 October 2026
Countries Visited: Italy, Sicily, Corsica, France (+1 more), Spain
Exclusive Deal
INSIDE
$1,588
OCEANVIEW
$1,732
BALCONY
$2,256
SUITE
$3,190
Save (per person) 837
From (per person) 1,588
View Trip
10 Day Classic Mediterranean From Bologna To Barcelona with Norwegian Cruise Line
Cruise
 (1)

10 Days (9 Nights) Bologna to Barcelona
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Viva
Departures: Aug 2026 to Oct 2026
Countries Visited: Italy, Croatia, Montenegro, France (+1 more), Spain
NCL's More at SeaExclusive Solo Offer
INSIDE
$4,507
OCEANVIEW
$5,119
BALCONY
$6,021
SUITE
$7,369
From (per person) 4,507
View Trip
10 Day Classic Mediterranean From Bologna To Barcelona with Norwegian Cruise Line
Cruise
 (1)

10 Days (9 Nights) Bologna to Barcelona
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Viva
Departure: 15 June 2026
Countries Visited: Italy, Montenegro, Croatia, France (+1 more), Spain
NCL's More at SeaExclusive Solo Offer
INSIDE
$4,512
OCEANVIEW
$5,124
BALCONY
$6,042
SUITE
$7,403
From (per person) 4,512
View Trip
8 Day Western Mediterranean: Italy, France & Gibraltar with Holland America
Cruise
 (2)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Holland America
Ship: Oosterdam
Departure: 29 August 2026
Countries Visited: Italy, Corsica, France, Gibraltar (+1 more), Spain
Exclusive Deal
INSIDE
$1,914
OCEANVIEW
$2,211
BALCONY
$2,706
SUITE
$4,191
From (per person) 1,914
View Trip
3 Day Mediterranean with MSC Cruises
Cruise
 (1)

3 Days (2 Nights) Genoa to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 21 April 2025
Countries Visited: Italy, Spain
Holiday Breaks Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$562
SUITE
-
From (per person) 562
View Trip
15 Day Mediterranean with Greek Isles, Italy & Turkey with Princess
Cruise
 (2)

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Princess
Ship: Sun Princess
Departures: Apr 2025 to May 2025
Countries Visited: Italy, Greece, Turkey, Montenegro (+2 more), Sicily, Spain
Exclusive Deal
INSIDE
$4,987
OCEANVIEW
$6,324
BALCONY
$7,601
SUITE
$8,749
From (per person) 4,987
View Trip
8 Day Mediterranean Passage with Oceania Cruises
Cruise
 (1)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 02 December 2026
Countries Visited: Italy, Corsica, France, Spain
Exclusive Deal
INSIDE
$3,020
OCEANVIEW
$3,317
BALCONY
$4,822
SUITE
$6,782
Save (per person) 2,020
From (per person) 3,020
View Trip
12 Day Rivieras & Yacht Havens Voyage with Azamara Cruises
Cruise
 (3)

12 Days (11 Nights) Rome to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 26 August 2025
Countries Visited: Italy, Monaco, France, Spain
INSIDE
$4,714
OCEANVIEW
$5,080
BALCONY
$6,239
SUITE
$7,397
From (per person) 4,714
View Trip
15 Day Canary Islands And Madeira with MSC Cruises
Cruise
 (1)

15 Days (14 Nights) Genoa to Santa Cruz De Tenerife
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 02 November 2025
Countries Visited: Italy, France, Spain, Gibraltar (+1 more), Portugal
Seasational Sale
INSIDE
-
OCEANVIEW
$2,493
BALCONY
$3,325
SUITE
-
From (per person) 2,493
View Trip
11 Day Italy & Spain Cruise: Florence, Marseilles & Barcelona with Azamara Cruises
Cruise
 (3)

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 03 March 2027
Countries Visited: Italy, France, Spain
INSIDE
$4,170
OCEANVIEW
$4,764
BALCONY
$5,912
SUITE
$8,793
From (per person) 4,170
View Trip
11 Day Mediterranean with MSC Cruises
Cruise
 (1)

11 Days (10 Nights) Trieste to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 29 October 2025
Countries Visited: Italy, Croatia, Greece, Malta (+2 more), Sicily, Spain
Seasational Sale
INSIDE
-
OCEANVIEW
-
BALCONY
$2,193
SUITE
$3,133
From (per person) 2,193
View Trip
8 Day Mediterranean Cruise: Itlay, France & Spain with Azamara Cruises
Cruise
 (1)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 07 November 2026
Countries Visited: Italy, France, Spain
INSIDE
$2,908
OCEANVIEW
$3,393
BALCONY
$3,809
SUITE
$6,036
From (per person) 2,908
View Trip
11 Day Dalmatian & Italian Gems with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Venice to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 10 August 2026
Countries Visited: Italy, Croatia, Montenegro, Greece (+2 more), Sicily, Spain
Exclusive Deal
INSIDE
$4,827
OCEANVIEW
$5,351
BALCONY
$7,985
SUITE
$10,994
Save (per person) 2,033
From (per person) 4,827
View Trip
8 Day Mediterranean Cruise From Rome To Barcelona with Norwegian Cruise Line
Cruise
 (1)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Epic
Departures: May 2026 to Oct 2026
Countries Visited: Italy, Sicily, France, Spain
NCL's More at SeaExclusive Solo Offer
INSIDE
$2,658
OCEANVIEW
-
BALCONY
$3,270
SUITE
$3,576
From (per person) 2,658
View Trip
15 Day Mediterranean & Italian Sojourn with Viking Cruises
Cruise
 (5)

15 Days (14 Nights) Venice to Barcelona
Operated By: Viking Cruises
Ships: Viking Jupiter, Viking Mars (+7 more), Viking Mira, Viking Neptune, Viking Saturn, Viking Sea, Viking Sky, Viking Vela, Viking Vesta
Departures: May 2025 to Aug 2027
Countries Visited: Italy, Croatia, Sicily, Monaco (+2 more), France, Spain
Companion Fly Free
INSIDE
-
OCEANVIEW
-
BALCONY
$12,441
SUITE
$17,831
Save (per person) 568
From (per person) 12,441
View Trip
12 Day Grand Western Mediterranean with Princess
Cruise
 (2)

12 Days (11 Nights) Rome to Barcelona
Cruise Line: Princess
Ship: Sun Princess
Departure: 29 July 2025
Countries Visited: Italy, Sicily, France, Spain (+1 more), Gibraltar
Exclusive Deal
INSIDE
$2,361
OCEANVIEW
$2,915
BALCONY
$3,302
SUITE
$3,806
From (per person) 2,361
View Trip
3 Day Mediterranean with MSC Cruises
Cruise
 (1)

3 Days (2 Nights) Rome to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Orchestra
Departure: 16 April 2025
Countries Visited: Italy, Spain
Holiday Breaks Offer
INSIDE
$443
OCEANVIEW
$512
BALCONY
$661
SUITE
$1,017
From (per person) 443
View Trip
12 Day Around Italy's Boot: Cote D'azur with Holland America
Cruise
 (2)

12 Days (11 Nights) Trieste to Barcelona
Cruise Line: Holland America
Ship: Oosterdam
Departure: 30 August 2025
Countries Visited: Italy, Montenegro, Greece, Sicily (+2 more), France, Spain
Exclusive Deal
INSIDE
$2,546
OCEANVIEW
$2,843
BALCONY
$3,326
SUITE
$5,095
From (per person) 2,546
View Trip
8 Day Italy, Spain & French Riviera with Royal Caribbean
Cruise
 (2)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Royal Caribbean
Ship: Brilliance of the Seas
Departure: 07 September 2026
Countries Visited: Italy, France, Spain
Exclusive Deal
INSIDE
$1,755
OCEANVIEW
$1,836
BALCONY
$2,590
SUITE
$3,881
Save (per person) 946
From (per person) 1,755
View Trip
15 Day Mediterranean with Greek Isles, Italy & Turkey with Princess
Cruise
 (2)

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Princess
Ship: Sun Princess
Departures: Apr 2026 to Sep 2026
Countries Visited: Italy, Greece, Turkey, Montenegro (+2 more), Sicily, Spain
Exclusive Deal
INSIDE
$3,868
OCEANVIEW
$4,839
BALCONY
$5,917
SUITE
$6,591
From (per person) 3,868
View Trip
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