Home > Cruises > Europe Cruises > Mediterranean Cruises > Cruises from Italy to Spain

Cruises from Italy to Spain

Are you looking for a cruise from Italy to Spain? September is the most popular month to cruise between Italy and Spain and there are 231 departures available from sixteen of the world's leading cruise lines.
Filter Results
Departures
Show More...
Duration
2 Days
31 Days
Start & End Cities
Ship Size
Ship Features
Operators
Show More...
Price
$200pp
$50,670pp
Countries
Show More...
Filter Results
129 Cruises (231 Cruise Departures)
13 Day Mediterranean Odyssey with Viking Cruises
Cruise

13 Days (12 Nights) Venice to Barcelona
Cruise Line: Viking Cruises
Ships: Viking Saturn, Viking Sea (+3 more), Viking Sky, Viking Star, Viking Vesta
Departures: Jul 2024 to Aug 2026
Countries Visited: Italy, Croatia, Greece, Monaco (+2 more), France, Spain
Discover More Sale
INSIDE
-
OCEANVIEW
-
BALCONY
$6,925
SUITE
$10,390
Save 1,122
From 6,925
View Trip
11 Day Grand Mediterranean with Princess
Cruise
 (3)

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Princess
Ship: Majestic Princess
Departure: 30 June 2025
Countries Visited: Italy, Greece, Turkey, Sicily (+1 more), Spain
Exclusive Deal
INSIDE
$3,012
OCEANVIEW
-
BALCONY
$4,378
SUITE
$5,308
From 3,012
View Trip
8 Day Iconic Western Mediterranean with Viking Cruises
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Viking Cruises
Ships: Viking Jupiter, Viking Mars (+7 more), Viking Neptune, Viking Saturn, Viking Sky, Viking Star, Viking Vela, Viking Venus, Viking Vesta
Departures: Nov 2024 to Sep 2026
Countries Visited: Italy, Monaco, France, Spain
Discover More Sale
INSIDE
-
OCEANVIEW
-
BALCONY
$4,252
SUITE
$6,232
Save 2,446
From 4,252
View Trip
22 Day Western Mediterranean: Lisbon Overnight with Holland America
Cruise
 (1)

22 Days (21 Nights) Rome to Barcelona
Cruise Line: Holland America
Ship: Oosterdam
Departure: 29 June 2025
Countries Visited: Italy, Sicily, Greece, Malta (+6 more), Tunisia, Sardinia, Spain, Morocco, Portugal, Gibraltar
Have It All Offer
INSIDE
$6,769
OCEANVIEW
$7,561
BALCONY
$8,997
SUITE
$12,066
From 6,769
View Trip
11 Day Renaissance Triumphs with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Riviera
Departure: 04 November 2024
Countries Visited: Italy, Sicily, Malta, France (+1 more), Spain
Exclusive DealSingles Special Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$6,478
SUITE
$9,091
Save 2,052
From 6,478
View Trip
12 Day Around Italy's Boot: Cote D'azur with Holland America
Cruise
 (1)

12 Days (11 Nights) Venice to Barcelona
Cruise Line: Holland America
Ship: Oosterdam
Departure: 30 August 2025
Countries Visited: Italy, Montenegro, Greece, Sicily (+2 more), France, Spain
Have It All Offer
INSIDE
$3,793
OCEANVIEW
$3,991
BALCONY
$4,981
SUITE
$6,862
From 3,793
View Trip
11 Day Mediterranean Melange with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 29 October 2025
Countries Visited: Italy, Sicily, Sardinia, Corsica (+3 more), Monaco, France, Spain
Exclusive Deal
INSIDE
$4,419
OCEANVIEW
$4,874
BALCONY
$7,320
SUITE
$9,854
Save 2,031
From 4,419
View Trip
10 Day Islands Of The Med Voyage with Azamara Cruises
Cruise
 (1)

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 18 October 2024
Countries Visited: Italy, Corsica, Sardinia, Spain
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$9,807
From 9,807
View Trip
11 Day Autumnal Mediterranean with Oceania Cruises
Cruise
 (2)

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 18 October 2025
Countries Visited: Italy, Sicily, Malta, Tunisia (+3 more), Monaco, France, Spain
Exclusive Deal
INSIDE
$4,726
OCEANVIEW
$5,181
BALCONY
$7,626
SUITE
$10,309
Save 2,034
From 4,726
View Trip
10 Day Cities Of The Western Med Voyage with Azamara Cruises
Cruise
 (1)

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 31 October 2024
Countries Visited: Italy, Monaco, France, Spain
Circle Club Voyage
INSIDE
$2,497
OCEANVIEW
$3,987
BALCONY
$4,762
SUITE
$6,831
From 2,497
View Trip
12 Day Rivieras & Yacht Havens Voyage with Azamara Cruises
Cruise
 (1)

12 Days (11 Nights) Rome to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 26 August 2025
Countries Visited: Italy, Monaco, France, Spain
INSIDE
$4,368
OCEANVIEW
$4,858
BALCONY
$5,548
SUITE
$7,617
From 4,368
View Trip
11 Day Adriatic & Med Gateways Voyage with Azamara Cruises
Cruise
 (1)

11 Days (10 Nights) Venice to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 01 June 2026
Countries Visited: Italy, Slovenia, Croatia, Montenegro (+2 more), Monaco, Spain
INSIDE
$5,093
OCEANVIEW
$5,928
BALCONY
$6,848
SUITE
$9,377
From 5,093
View Trip
9 Day Italy, France & Croatia Cruise with Royal Caribbean
Cruise

9 Days (8 Nights) Ravenna to Barcelona
Cruise Line: Royal Caribbean
Ship: Explorer of the Seas
Departure: 13 September 2025
Countries Visited: Italy, Croatia, France, Spain
Exclusive Deal
INSIDE
$2,020
OCEANVIEW
$2,935
BALCONY
$3,288
SUITE
$4,639
Save 812
From 1,750
View Trip
12 Day Rome to Barcelona with Silversea
Cruise

12 Days (11 Nights) Rome to Barcelona
Cruise Line: Silversea
Ship: Silver Ray
Departure: 12 November 2024
Countries Visited: Italy, Spain, Tunisia, Malta
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$10,444
Save 856
From 10,444
View Trip
21 Day Elegance In The Mediterranean with Regent Seven Seas
Cruise

21 Days (20 Nights) Venice to Barcelona
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 28 April 2025
Countries Visited: Italy, Croatia, Montenegro, Greece (+4 more), Malta, Sicily, France, Spain
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$23,744
SUITE
-
Save 9,116
From 23,744
View Trip
11 Day Greek Isles & Turkey with Celebrity Cruises
Cruise

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departures: Jul 2024 to Oct 2024
Countries Visited: Italy, Greece, Turkey, Malta (+1 more), Spain
Exclusive DealExclusive Offer
INSIDE
$2,613
OCEANVIEW
$2,711
BALCONY
$3,315
SUITE
$8,665
Save 3,518
From 2,613
View Trip
8 Day A Journey From Civitavecchia To Barcelona with Explora Journeys
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 29 September 2025
Countries Visited: Italy, Sicily, Tunisia, Sardinia (+1 more), Spain
Unique Escapes
INSIDE
-
OCEANVIEW
-
BALCONY
$5,846
SUITE
$7,108
From 5,846
View Trip
22 Day Italy, Spain And Adriatic with Cunard
Cruise

22 Days (21 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 01 June 2026
Countries Visited: Italy, Greece, Montenegro, Croatia (+3 more), Malta, Spain, France
Exclusive Deal
INSIDE
$3,620
OCEANVIEW
$3,867
BALCONY
$4,511
SUITE
$12,183
From 3,620
View Trip
8 Day Mediterranean with MSC Cruises
Cruise

8 Days (7 Nights) Genoa to Alicante
Cruise Line: MSC Cruises
Ships: MSC Musica, MSC Orchestra
Departures: Sep 2024 to Apr 2025
Countries Visited: Italy, France, Spain, Portugal
Early Booking OfferLast Minute Offer
INSIDE
$1,534
OCEANVIEW
$1,831
BALCONY
$1,960
SUITE
-
From 1,534
View Trip
15 Day Adriatic And Western Mediterranean with Cunard
Cruise

15 Days (14 Nights) Trieste to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 01 July 2024
Countries Visited: Italy, Croatia, Malta, France (+1 more), Spain
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$9,607
From 9,607
View Trip
15 Day Mediterranean with Greek Isles, Italy & Turkey with Princess
Cruise

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Princess
Ship: Sun Princess
Departures: Apr 2026 to Sep 2026
Countries Visited: Italy, Greece, Turkey, Montenegro (+2 more), Sicily, Spain
Exclusive Deal
INSIDE
$4,686
OCEANVIEW
$5,527
BALCONY
$5,993
SUITE
$7,755
From 4,686
View Trip
8 Day Western Mediterranean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Ravenna to Barcelona
Cruise Line: Royal Caribbean
Ship: Voyager of the Seas
Departure: 15 September 2025
Countries Visited: Italy, Sicily, France, Spain
Exclusive Deal
INSIDE
$1,683
OCEANVIEW
$2,338
BALCONY
$2,719
SUITE
$3,387
Save 693
From 1,502
View Trip
8 Day Spanish & Italian Hot Spots with Virgin Voyages
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Virgin Voyages
Ship: Scarlet Lady
Departure: 06 July 2025
Countries Visited: Italy, Sicily, Corsica, Spain
INSIDE
$2,562
OCEANVIEW
$2,995
BALCONY
$3,306
SUITE
$6,811
From 2,562
View Trip
18 Day Mediterranean Majesty with Regent Seven Seas
Cruise

18 Days (17 Nights) Rome to Barcelona
Cruise Line: Regent Seven Seas
Ship: Seven Seas Mariner
Departure: 17 October 2024
Countries Visited: Italy, France, Spain, Gibraltar (+2 more), Portugal, Morocco
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$45,233
Save 5,437
From 45,233
View Trip
12 Day Grand Mediterranean with Princess
Cruise

12 Days (11 Nights) Rome to Barcelona
Cruise Line: Princess
Ship: Sun Princess
Departure: 21 October 2025
Countries Visited: Italy, Greece, Turkey, Sicily (+1 more), Spain
Exclusive Deal
INSIDE
$3,317
OCEANVIEW
$4,238
BALCONY
$5,000
SUITE
$5,624
From 3,317
View Trip
13 Day Greek Isles, Italy & Turkey with Celebrity Cruises
Cruise

13 Days (12 Nights) Rome to Barcelona
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 23 September 2024
Countries Visited: Italy, Greece, Turkey, Malta (+1 more), Spain
Exclusive DealExclusive Offer
INSIDE
$3,692
OCEANVIEW
-
BALCONY
$7,553
SUITE
$11,659
Save 4,302
From 3,692
View Trip
11 Day Rome To Barcelona Cruise with Celebrity Cruises
Cruise

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Celebrity Cruises
Ship: Celebrity Constellation
Departure: 28 October 2024
Countries Visited: Italy, France, Spain
Exclusive DealExclusive Offer
INSIDE
$2,029
OCEANVIEW
$2,188
BALCONY
$2,538
SUITE
$6,662
Save 2,949
From 2,029
View Trip
31 Day Riviera, Mediterranean & Tyrrhenian Treasures with Seabourn
Cruise

31 Days (30 Nights) Rome to Barcelona
Cruise Line: Seabourn
Ship: Ovation
Departure: 10 August 2025
Countries Visited: Italy, Malta, Tunisia, France (+5 more), Spain, Sardinia, Monaco, Sicily, Corsica
The Sail Away Event
INSIDE
-
OCEANVIEW
-
BALCONY
$22,748
SUITE
$42,860
From 22,748
View Trip
4 Day Mediterranean with MSC Cruises
Cruise

4 Days (3 Nights) Rome to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 09 September 2024
Countries Visited: Italy, France, Spain
Early Booking With Easy Drink Package
INSIDE
-
OCEANVIEW
-
BALCONY
$1,025
SUITE
-
From 1,025
View Trip
8 Day Italy, France And Spain with Cunard
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 08 July 2024
Countries Visited: Italy, France, Spain
Exclusive Deal
INSIDE
$1,981
OCEANVIEW
$2,278
BALCONY
$2,674
SUITE
$5,149
From 1,981
View Trip
Results: 1-30 of 129

No Results found. Try changing your search filters.




Cruises found! Scroll up to view

Europe Cruises

All Europe Cruises Adriatic Cruises Aegean Cruises Baltic Cruises Black Sea Cruises Croatia Cruises Med Cruises Greek Islands Cruises UK Cruises Western Europe Cruises

Travel Styles

Festivals & Events Luxury Cruises Short Cruise Breaks

Countries

Corsica Croatia Cyprus Egypt England France Gibraltar Israel Italy Malta Monaco Montenegro Morocco Portugal Sardinia Sicily Spain Tunisia Turkey

Cities

Genoa Naples Ravenna Rome Trieste Venice

Routes

Cruises from Rome to Barcelona Cruises from Trieste to Barcelona Cruises from Venice to Barcelona

Country Routes

Cruises from Italy to Spain

Cruise Lines Exploring The Med

APT Med Cruises Azamara Med Cruises Celebrity Med Cruises Cunard Med Cruises Emerald Med Cruises G Adventures Med Cruises Intrepid Med Cruises MSC Med Cruises NCL Med Cruises Oceania Med Cruises P&O (UK) Med Cruises Princess Med Cruises Regent Seven Seas Med Cruises Royal Caribbean Med Cruises Scenic Med Cruises Silversea Med Cruises Viking Med Cruises Virgin Voyages Med Cruises

© 2010-2024. Global Journeys. You're viewing our site in Australian dollars.

    

About Us | View Your Booking | Terms & Conditions | Site Map | We're Hiring!

Global Journeys Pty Ltd. Member of The Australian Travel Industry Association (AITA) & ATAS Travel Accredited (No. A11351).

Travel Industry Associations