Home > Cruises > Europe Cruises > Mediterranean Cruises > Cruises from Italy to USA

Cruises from Italy to USA

Are you looking for a cruise from Italy to USA? October is the most popular month to cruise between Italy and USA and there are 38 departures available from eleven of the world's leading cruise lines.
Filter Results
Departures
Duration
14 Days
58 Days
Start & End Cities
Ship Size
Ship Features
Operators
Show More...
Price
$1,600pp
$42,760pp
Countries
Show More...
Filter Results
38 Cruises (38 Cruise Departures)
15 Day Cultural Crossing With Andalusia And Azores with Holland America
Cruise
 (2)

15 Days (14 Nights) Rome to Fort Lauderdale
Cruise Line: Holland America
Ship: Nieuw Statendam
Departure: 15 November 2025
Countries Visited: Italy, Spain, Gibraltar, Portugal (+1 more), USA
Exclusive Deal
INSIDE
$1,843
OCEANVIEW
$1,942
BALCONY
$2,090
SUITE
$4,070
From (per person) 1,843
View Trip
22 Day Atlantic Crossing & Mediterranean with Viking Cruises
Cruise
 (5)

22 Days (21 Nights) Rome to Fort Lauderdale
Operated By: Viking Cruises
Ship: Viking Sky
Departure: 28 November 2025
Countries Visited: Italy, Monaco, France, Spain (+3 more), Portugal, Sint Maarten, USA
Companion Fly Free
INSIDE
-
OCEANVIEW
-
BALCONY
$13,029
SUITE
$18,811
Save (per person) 266
From (per person) 13,029
View Trip
17 Day Moroccan Passage with Princess
Cruise
 (1)

17 Days (16 Nights) Rome to Fort Lauderdale
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 17 November 2026
Countries Visited: Italy, Spain, Gibraltar, Morocco (+1 more), USA
Exclusive Deal
INSIDE
$1,658
OCEANVIEW
$2,946
BALCONY
$2,525
SUITE
$3,204
From (per person) 1,658
View Trip
27 Day Mediterranean Grand Adventure with Princess
Cruise
 (2)

27 Days (26 Nights) Rome to Fort Lauderdale
Cruise Line: Princess
Ship: Sun Princess
Departure: 21 October 2025
Countries Visited: Italy, Greece, Turkey, Sicily (+3 more), Spain, Gibraltar, USA
Exclusive Deal
INSIDE
$4,645
OCEANVIEW
$6,130
BALCONY
$7,437
SUITE
$10,555
From (per person) 4,645
View Trip
24 Day Mediterranean, Aegean & Moroccan Passage with Princess
Cruise
 (1)

24 Days (23 Nights) Rome to Fort Lauderdale
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 10 November 2026
Countries Visited: Italy, Greece, Turkey, Spain (+3 more), Gibraltar, Morocco, USA
Exclusive Deal
INSIDE
$3,724
OCEANVIEW
$5,969
BALCONY
$5,632
SUITE
$6,524
From (per person) 3,724
View Trip
34 Day Mediterranean, Iceland & British Isles Grand Adventure with Princess
Cruise
 (3)

34 Days (33 Nights) Rome to Boston
Cruise Line: Princess
Ship: Majestic Princess
Departure: 30 June 2025
Countries Visited: Italy, Greece, Turkey, Sicily (+6 more), Spain, Gibraltar, England, Iceland, Canada, USA
Exclusive Deal
INSIDE
$9,133
OCEANVIEW
-
BALCONY
$9,033
SUITE
$13,978
From (per person) 9,033
View Trip
35 Day Mediterranean Jewels & Atlantic Crossing with Seabourn
Cruise

35 Days (34 Nights) Rome to Miami
Cruise Line: Seabourn
Ship: Seabourn Sojourn
Departure: 15 November 2026
Countries Visited: Italy, Corsica, Sardinia, Sicily (+7 more), Malta, Tunisia, Spain, Gibraltar, Morocco, Portugal, USA
Exclusive Deal
INSIDE
-
OCEANVIEW
$21,316
BALCONY
$24,385
SUITE
$44,581
From (per person) 21,316
View Trip
22 Day Atlantic Ocean Isles with Regent Seven Seas
Cruise

22 Days (21 Nights) Rome to Miami
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 08 November 2026
Countries Visited: Italy, Spain, Gibraltar, Portugal (+5 more), Bermuda, USA, Honduras, Belize, Mexico
Upgrade Your HorizonExclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$15,405
SUITE
$16,435
Save (per person) 8,275
From (per person) 15,405
View Trip
26 Day Rome to Fort Lauderdale with Silversea
Cruise

26 Days (25 Nights) Rome to Fort Lauderdale
Cruise Line: Silversea
Ship: Silver Ray
Departure: 07 November 2025
Countries Visited: Italy, France, Spain, Portugal (+2 more), Bermuda, USA
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$16,830
From (per person) 16,830
View Trip
17 Day Spain & Bermuda Transatlantic with Celebrity Cruises
Cruise

17 Days (16 Nights) Rome to Tampa
Cruise Line: Celebrity Cruises
Ship: Celebrity Constellation
Departure: 31 October 2025
Countries Visited: Italy, Spain, Portugal, Bermuda (+2 more), Bahamas, USA
Endless Summer Sale
INSIDE
$2,212
OCEANVIEW
$2,418
BALCONY
$3,763
SUITE
$7,784
Save (per person) 1,194
From (per person) 2,212
View Trip
27 Day Civitavecchia to Miami with Silversea
Cruise

27 Days (26 Nights) Rome to Miami
Cruise Line: Silversea
Ship: Silver Dawn
Departure: 25 November 2026
Countries Visited: Italy, Malta, Sicily, Tunisia (+4 more), Sardinia, Spain, Portugal, USA
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
-
BALCONY
$15,444
SUITE
$25,146
From (per person) 15,444
View Trip
15 Day Spain & Portugal Transatlantic with Royal Caribbean
Cruise

15 Days (14 Nights) Rome to New York
Cruise Line: Royal Caribbean
Ship: Odyssey of the Seas
Departure: 25 October 2026
Countries Visited: Italy, Spain, Portugal, USA
Exclusive DealExclusive Solo Offer
INSIDE
$2,253
OCEANVIEW
$2,685
BALCONY
$3,015
SUITE
-
Save (per person) 1,145
From (per person) 2,253
View Trip
15 Day Italy & Bermuda Transatlantic with Celebrity Cruises
Cruise

15 Days (14 Nights) Rome to Fort Lauderdale
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 30 October 2026
Countries Visited: Italy, Sardinia, Spain, Portugal (+2 more), Bermuda, USA
Endless Summer SaleSolo Offer + Onboard Credit
INSIDE
$2,437
OCEANVIEW
$2,863
BALCONY
$3,584
SUITE
$8,867
Save (per person) 1,410
From (per person) 2,437
View Trip
21 Day Transatlantic with MSC Cruises
Cruise

21 Days (20 Nights) Rome to Miami
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 17 October 2025
Countries Visited: Italy, France, Spain, Portugal (+4 more), Antigua and Barbuda, Sint Maarten, Puerto Rico, USA
Mutiple Deals Available
INSIDE
$2,731
OCEANVIEW
$3,166
BALCONY
$3,909
SUITE
$6,037
From (per person) 2,731
View Trip
18 Day MSC Grand Voyages with MSC Cruises
Cruise

18 Days (17 Nights) Rome to Miami
Cruise Line: MSC Cruises
Ship: MSC Poesia
Departure: 06 April 2026
Countries Visited: Italy, France, Spain, Portugal (+3 more), Saint Martin, Bahamas, USA
Flash Sale + Onboard Credit
INSIDE
$1,855
OCEANVIEW
$2,112
BALCONY
$2,934
SUITE
-
From (per person) 1,855
View Trip
26 Day Europe To The Caribbean with Oceania Cruises
Cruise

26 Days (25 Nights) Rome to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 15 November 2026
Countries Visited: Italy, Sicily, Malta, Tunisia (+6 more), Sardinia, Spain, Portugal, Puerto Rico, Bahamas, USA
Exclusive Deal
INSIDE
$9,959
OCEANVIEW
$12,207
BALCONY
$14,167
SUITE
$19,127
Save (per person) 2,071
From (per person) 9,959
View Trip
22 Day Transatlantic with MSC Cruises
Cruise

22 Days (21 Nights) Naples to Miami
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 16 October 2025
Countries Visited: Italy, France, Spain, Portugal (+4 more), Antigua and Barbuda, Sint Maarten, Puerto Rico, USA
Early Booking OfferSeasational Sale
INSIDE
$2,947
OCEANVIEW
$3,382
BALCONY
$3,679
SUITE
$6,263
From (per person) 2,947
View Trip
17 Day MSC Grand Voyages with MSC Cruises
Cruise

17 Days (16 Nights) Genoa to Miami
Cruise Line: MSC Cruises
Ship: MSC Poesia
Departure: 07 April 2026
Countries Visited: Italy, France, Spain, Portugal (+3 more), Saint Martin, Bahamas, USA
Early Booking OfferSeasational Sale
INSIDE
$2,015
OCEANVIEW
$2,262
BALCONY
$2,678
SUITE
-
From (per person) 2,015
View Trip
58 Day Old & New World Discovery with Oceania Cruises
Cruise

58 Days (57 Nights) Venice to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 23 October 2026
Countries Visited: Italy, Croatia, Montenegro, Greece (+14 more), Sicily, Spain, Portugal, Puerto Rico, Bahamas, USA, Virgin Islands, Antigua and Barbuda, Saint Lucia, Trinidad and Tobago, Brazil, Barbados, Dominica, Saint Martin
Exclusive Deal
INSIDE
$22,337
OCEANVIEW
$24,594
BALCONY
$34,662
SUITE
$48,047
Save (per person) 2,143
From (per person) 22,337
View Trip
26 Day A Grand Journey Of European Gems And Tropical Idylls with Explora Journeys
Cruise

26 Days (25 Nights) Venice to Miami
Cruise Line: Explora Journeys
Ship: Explora I
Departure: 18 October 2025
Countries Visited: Italy, Croatia, Montenegro, Monaco (+6 more), Spain, Portugal, Antigua and Barbuda, Virgin Islands, Puerto Rico, USA
Unique Oceans Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$19,602
SUITE
$21,047
From (per person) 19,602
View Trip
31 Day A Journey Of Sun And Sea with Regent Seven Seas
Cruise

31 Days (30 Nights) Rome to Miami
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 25 October 2025
Countries Visited: Italy, Sicily, Malta, Tunisia (+7 more), Corsica, Monaco, Spain, Portugal, Bermuda, Bahamas, USA
Upgrade Your Horizon
INSIDE
-
OCEANVIEW
-
BALCONY
$28,848
SUITE
$31,066
Save (per person) 13,912
From (per person) 28,848
View Trip
14 Day Italy & Bermuda Transatlantic with Celebrity Cruises
Cruise

14 Days (13 Nights) Rome to Fort Lauderdale
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 31 October 2025
Countries Visited: Italy, Sardinia, Gibraltar, Bermuda (+1 more), USA
Endless Summer Sale
INSIDE
$2,258
OCEANVIEW
$3,328
BALCONY
$4,760
SUITE
$9,936
Save (per person) 1,371
From (per person) 2,258
View Trip
20 Day MSC Grand Voyages with MSC Cruises
Cruise

20 Days (19 Nights) Genoa to Miami
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 18 October 2025
Countries Visited: Italy, France, Spain, Portugal (+4 more), Antigua and Barbuda, Sint Maarten, Puerto Rico, USA
Early Booking OfferSeasational Sale
INSIDE
$2,762
OCEANVIEW
$3,148
BALCONY
$3,841
SUITE
$5,732
From (per person) 2,762
View Trip
22 Day Riviera Gems & Atlantic Crossing with Seabourn
Cruise

22 Days (21 Nights) Rome to Miami
Cruise Line: Seabourn
Ship: Seabourn Encore
Departure: 11 November 2025
Countries Visited: Italy, Corsica, Sardinia, Spain (+3 more), Portugal, Bermuda, USA
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$12,294
SUITE
$43,242
From (per person) 12,294
View Trip
57 Day Antiquity To America with Oceania Cruises
Cruise

57 Days (56 Nights) Rome to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 04 October 2025
Countries Visited: Italy, Sicily, Malta, Greece (+12 more), Turkey, Cyprus, Croatia, Montenegro, Tunisia, Spain, Morocco, Portugal, Barbados, Antigua and Barbuda, Puerto Rico, USA
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$32,392
SUITE
$46,074
Save (per person) 2,258
From (per person) 32,392
View Trip
22 Day Jewels Of Andalusia & Atlantic Crossing with Seabourn
Cruise

22 Days (21 Nights) Rome to Miami
Cruise Line: Seabourn
Ship: Seabourn Quest
Departure: 01 November 2026
Countries Visited: Italy, Corsica, Sardinia, Spain (+2 more), Portugal, USA
Exclusive Deal
INSIDE
-
OCEANVIEW
$13,384
BALCONY
$15,859
SUITE
$28,432
From (per person) 13,384
View Trip
17 Day MSC Grand Voyages with MSC Cruises
Cruise

17 Days (16 Nights) Genoa to Miami
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 19 November 2025
Countries Visited: Italy, France, Spain, Puerto Rico (+2 more), Virgin Islands, USA
Early Booking OfferEarly Booking Drinks Package
INSIDE
$1,757
OCEANVIEW
$2,203
BALCONY
$2,401
SUITE
$4,559
From (per person) 1,757
View Trip
26 Day Allura Autumn Crossing with Oceania Cruises
Cruise

26 Days (25 Nights) Rome to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 07 November 2026
Countries Visited: Italy, Sicily, Malta, Tunisia (+5 more), Sardinia, Spain, Morocco, Puerto Rico, USA
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$14,019
SUITE
$18,979
Save (per person) 2,111
From (per person) 14,019
View Trip
23 Day MSC Grand Voyages with MSC Cruises
Cruise

23 Days (22 Nights) Amalfi to New York
Cruise Line: MSC Cruises
Ship: MSC Meraviglia
Departure: 17 October 2026
Countries Visited: Italy, France, Spain, Gibraltar (+2 more), Portugal, USA
Early Booking Offer
INSIDE
$3,242
OCEANVIEW
$3,786
BALCONY
$4,074
SUITE
-
From (per person) 3,242
View Trip
36 Day MSC Grand Voyages with MSC Cruises
Cruise

36 Days (35 Nights) Rome to Seattle
Cruise Line: MSC Cruises
Ship: MSC Poesia
Departure: 06 April 2026
Countries Visited: Italy, France, Spain, Portugal (+7 more), Saint Martin, Bahamas, USA, Colombia, Panama, Costa Rica, Mexico
Early Booking Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$8,268
SUITE
-
From (per person) 8,268
View Trip
Results: 1-30 of 38

No Results found. Try changing your search filters.




Cruises found! Scroll up to view

Europe Cruises

All Europe Cruises Adriatic Cruises Aegean Cruises Baltic Cruises Black Sea Cruises Croatia Cruises Med Cruises Greek Islands Cruises UK Cruises Western Europe Cruises

Travel Styles

Festivals & Events Food & Wine Cruises Luxury Cruises Short Cruise Breaks

Countries

Albania Corsica Croatia Cyprus England France Gibraltar Italy Malta Mexico Monaco Montenegro Morocco Portugal Sardinia Sicily Spain Tunisia Turkey USA

Cities

Amalfi Genoa Naples Rome Venice

Routes

Cruises from Rome to Miami Cruises from Rome to Fort Lauderdale

Country Routes

Cruises from Italy to USA

Cruise Lines Exploring The Med

Azamara Med Cruises Celebrity Med Cruises Cunard Med Cruises Emerald Med Cruises G Adventures Med Cruises Intrepid Med Cruises MSC Med Cruises NCL Med Cruises Oceania Med Cruises P&O (UK) Med Cruises Ponant Med Cruises Princess Med Cruises Regent Seven Seas Med Cruises Royal Caribbean Med Cruises Scenic Med Cruises Silversea Med Cruises Viking Med Cruises Virgin Voyages Med Cruises

© 2010-2025. Global Journeys. You're viewing our site in Australian dollars.

    

About Us | View Your Booking | Terms & Conditions | Site Map

Global Journeys Pty Ltd. Accredited Member of The Australian Travel Industry Association (AITA). No. A11351.

Travel Industry Associations