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MSC Cruises from Orlando

Start your journey from Orlando with 50 unique MSC cruise itineraries to choose from. December and February are the most popular months to begin your cruise from Orlando and MSC Cruises have 179 trips departing this season.
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4 Days
22 Days
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50 Cruises (179 Cruise Departures)
21 Day MSC Grand Voyages with MSC Cruises
Cruise

21 Days (20 Nights) Orlando to Palma de Mallorca
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 18 April 2026
Countries Visited: USA, Saint Martin, Portugal, Spain (+2 more), France, Italy
Early Booking Offer
INSIDE
$2,791
OCEANVIEW
$3,355
BALCONY
$3,603
SUITE
-
From (per person) 2,791
View Trip
8 Day Caribbean And Antilles with MSC Cruises
Cruise

8 Days (7 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departures: Feb 2026 to Mar 2026
Countries Visited: USA, Mexico, Cayman Islands, Jamaica (+1 more), Bahamas
Seasational Sale
INSIDE
$1,163
OCEANVIEW
$1,529
BALCONY
$1,757
SUITE
$3,024
From (per person) 1,163
View Trip
13 Day Caribbean And Antilles with MSC Cruises
Cruise

13 Days (12 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departure: 21 December 2025
Countries Visited: USA, Bahamas, Jamaica, Mexico
Seasational Sale
INSIDE
-
OCEANVIEW
-
BALCONY
$3,734
SUITE
$6,031
From (per person) 3,734
View Trip
7 Day Caribbean And Antilles with MSC Cruises
Cruise

7 Days (6 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 18 January 2026
Countries Visited: USA, Bahamas, Dominican Republic
Seasational Sale
INSIDE
$952
OCEANVIEW
$1,219
BALCONY
$1,358
SUITE
$2,338
From (per person) 952
View Trip
8 Day Caribbean And Antilles with MSC Cruises
Cruise

8 Days (7 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departure: 23 November 2025
Countries Visited: USA, Puerto Rico, Bahamas
Seasational Sale
INSIDE
$1,252
OCEANVIEW
$1,529
BALCONY
$1,886
SUITE
$3,341
From (per person) 1,252
View Trip
15 Day Caribbean And Antilles with MSC Cruises
Cruise

15 Days (14 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departures: Dec 2025 to Mar 2026
Countries Visited: USA, Bahamas, Dominican Republic, Mexico (+2 more), Cayman Islands, Jamaica
Seasational SaleFlash Sale + Onboard Credit
INSIDE
$2,029
OCEANVIEW
$2,662
BALCONY
$3,019
SUITE
$6,593
From (per person) 2,029
View Trip
8 Day Caribbean And Antilles with MSC Cruises
Cruise

8 Days (7 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 20 December 2025
Countries Visited: USA, Bahamas, Puerto Rico
Seasational Sale
INSIDE
$1,460
OCEANVIEW
$1,826
BALCONY
$2,054
SUITE
$3,401
From (per person) 1,460
View Trip
5 Day Caribbean & Antilles with MSC Cruises
Cruise

5 Days (4 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departures: May 2026 to Nov 2026
Countries Visited: USA, Bahamas
Early Booking Offer
INSIDE
$657
OCEANVIEW
$766
BALCONY
$865
SUITE
$1,301
From (per person) 657
View Trip
22 Day MSC Grand Voyages with MSC Cruises
Cruise

22 Days (21 Nights) Orlando to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 11 April 2026
Countries Visited: USA, Bahamas, Dominican Republic, Saint Martin (+2 more), Portugal, Spain
Early Booking Offer
INSIDE
$2,943
OCEANVIEW
$3,527
BALCONY
$4,062
SUITE
$6,814
From (per person) 2,943
View Trip
11 Day Caribbean And Antilles with MSC Cruises
Cruise

11 Days (10 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departures: Jul 2025 to Oct 2025
Countries Visited: USA, Bahamas, Honduras, Mexico
Flash Sale + Onboard CreditSeasational Sale
INSIDE
$1,817
OCEANVIEW
$2,035
BALCONY
$2,480
SUITE
$4,401
From (per person) 1,817
View Trip
15 Day Caribbean And Antilles with MSC Cruises
Cruise

15 Days (14 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 24 January 2026
Countries Visited: USA, Bahamas, Puerto Rico, Dominican Republic
Seasational Sale
INSIDE
$2,098
OCEANVIEW
$2,732
BALCONY
$3,088
SUITE
$7,335
From (per person) 2,098
View Trip
8 Day Caribbean And Antilles with MSC Cruises
Cruise

8 Days (7 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departure: 16 March 2025
Countries Visited: USA, Bahamas, Honduras, Mexico
Last Minute Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$1,767
SUITE
-
From (per person) 1,767
View Trip
15 Day Caribbean And Antilles with MSC Cruises
Cruise

15 Days (14 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departures: Feb 2026 to Mar 2026
Countries Visited: USA, Mexico, Cayman Islands, Jamaica (+2 more), Bahamas, Dominican Republic
Seasational Sale
INSIDE
$2,326
OCEANVIEW
$2,959
BALCONY
$3,316
SUITE
$7,563
From (per person) 2,326
View Trip
12 Day Caribbean And Antilles with MSC Cruises
Cruise

12 Days (11 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departures: Mar 2025 to May 2025
Countries Visited: USA, Bahamas, Mexico
Mutiple Deals Available
INSIDE
$2,315
OCEANVIEW
$2,563
BALCONY
$2,939
SUITE
$3,810
From (per person) 2,315
View Trip
5 Day Caribbean And Antilles with MSC Cruises
Cruise

5 Days (4 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ships: MSC Grandiosa, MSC Seashore
Departures: Jul 2025 to Apr 2026
Countries Visited: USA, Bahamas
Mutiple Deals Available
INSIDE
$578
OCEANVIEW
$737
BALCONY
$865
SUITE
$1,301
From (per person) 578
View Trip
17 Day MSC Grand Voyages with MSC Cruises
Cruise

17 Days (16 Nights) Orlando to Genoa
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 18 April 2026
Countries Visited: USA, Saint Martin, Portugal, Spain (+2 more), France, Italy
Early Booking Offer
INSIDE
$2,184
OCEANVIEW
$2,629
BALCONY
$2,827
SUITE
$11,352
From (per person) 2,184
View Trip
5 Day Caribbean And Antilles with MSC Cruises
Cruise

5 Days (4 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departures: Mar 2025 to Mar 2026
Countries Visited: USA, Bahamas
Mutiple Deals Available
INSIDE
$598
OCEANVIEW
$756
BALCONY
$905
SUITE
$1,420
From (per person) 598
View Trip
15 Day Caribbean And Antilles with MSC Cruises
Cruise

15 Days (14 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 28 March 2026
Countries Visited: USA, Bahamas, Dominican Republic, Mexico (+1 more), Belize
Seasational Sale
INSIDE
$2,484
OCEANVIEW
$3,118
BALCONY
$3,474
SUITE
$6,751
From (per person) 2,484
View Trip
5 Day Caribbean And Antilles with MSC Cruises
Cruise

5 Days (4 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ships: MSC Grandiosa, MSC Seashore
Departures: Jan 2026 to Apr 2026
Countries Visited: USA, Bahamas
Early Booking OfferSeasational Sale
INSIDE
$598
OCEANVIEW
$776
BALCONY
$875
SUITE
$1,360
From (per person) 598
View Trip
15 Day MSC Grand Voyages with MSC Cruises
Cruise

15 Days (14 Nights) Orlando to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 18 April 2026
Countries Visited: USA, Saint Martin, Portugal, Spain
Early Booking Offer
INSIDE
$1,949
OCEANVIEW
$2,336
BALCONY
$2,504
SUITE
$7,989
From (per person) 1,949
View Trip
16 Day MSC Grand Voyages with MSC Cruises
Cruise

16 Days (15 Nights) Orlando to Cannes
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 18 April 2026
Countries Visited: USA, Saint Martin, Portugal, Spain (+1 more), France
Early Booking Offer
INSIDE
$2,091
OCEANVIEW
-
BALCONY
$2,656
SUITE
-
From (per person) 2,091
View Trip
8 Day Caribbean And Antilles with MSC Cruises
Cruise

8 Days (7 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departures: Dec 2025 to Apr 2026
Countries Visited: USA, Bahamas, Dominican Republic
Mutiple Deals Available
INSIDE
$1,015
OCEANVIEW
$1,381
BALCONY
$1,609
SUITE
$2,658
From (per person) 1,015
View Trip
8 Day Caribbean And Antilles with MSC Cruises
Cruise

8 Days (7 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departure: 21 December 2025
Countries Visited: USA, Bahamas, Jamaica
Seasational Sale
INSIDE
$1,539
OCEANVIEW
$1,836
BALCONY
$2,193
SUITE
$3,153
From (per person) 1,539
View Trip
8 Day Caribbean And Antilles with MSC Cruises
Cruise

8 Days (7 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departures: Dec 2025 to Mar 2026
Countries Visited: USA, Mexico, Cayman Islands, Jamaica (+1 more), Bahamas
Seasational SaleFlash Sale + Onboard Credit
INSIDE
$1,084
OCEANVIEW
$1,450
BALCONY
$1,678
SUITE
$3,094
From (per person) 1,084
View Trip
11 Day Caribbean And Antilles with MSC Cruises
Cruise

11 Days (10 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departures: Mar 2025 to Oct 2025
Countries Visited: USA, Bahamas, Mexico
Mutiple Deals Available
INSIDE
$1,817
OCEANVIEW
$2,035
BALCONY
$2,375
SUITE
$3,672
From (per person) 1,817
View Trip
5 Day Caribbean And Antilles with MSC Cruises
Cruise

5 Days (4 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departures: Jun 2025 to Sep 2025
Countries Visited: USA, Bahamas
Seasational SaleFlash Sale + Onboard Credit
INSIDE
$796
OCEANVIEW
$895
BALCONY
$1,063
SUITE
$1,459
From (per person) 796
View Trip
12 Day Caribbean And Antilles with MSC Cruises
Cruise

12 Days (11 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departure: 23 November 2025
Countries Visited: USA, Puerto Rico, Bahamas
Seasational Sale
INSIDE
$1,771
OCEANVIEW
$2,177
BALCONY
$2,632
SUITE
$4,048
From (per person) 1,771
View Trip
8 Day Caribbean And Antilles with MSC Cruises
Cruise

8 Days (7 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departures: Jan 2026 to Jan 2026
Countries Visited: USA, Bahamas, Puerto Rico, Dominican Republic
Seasational Sale
INSIDE
$1,084
OCEANVIEW
$1,450
BALCONY
$1,678
SUITE
$2,945
From (per person) 1,084
View Trip
6 Day Caribbean And Antilles with MSC Cruises
Cruise

6 Days (5 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departure: 28 December 2025
Countries Visited: USA, Bahamas, Mexico
Seasational Sale
INSIDE
$1,265
OCEANVIEW
$1,443
BALCONY
$1,631
SUITE
$2,582
From (per person) 1,265
View Trip
12 Day Caribbean And Antilles with MSC Cruises
Cruise

12 Days (11 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departure: 16 March 2025
Countries Visited: USA, Bahamas, Honduras, Mexico
Save And Sail Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$2,794
SUITE
-
From (per person) 2,794
View Trip
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