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Cruises From Panama City

Choose from 15 unique cruises starting in Panama City, and travelling to Bridgetown, Fort Lauderdale, Hong Kong, Honolulu, Los Angeles and more. December is the most popular month to join a cruise from Panama City and you can select from 18 departures available from seven leading cruise lines.
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10 Days
38 Days
End City
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$4,400pp
$39,050pp
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15 Cruises (18 Cruise Departures)
11 Day Canal & Caribbean Discovery with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 27 January 2026
Countries Visited: Panama, Colombia, Bonaire, Curacao (+3 more), Aruba, Jamaica, USA
Exclusive Deal
INSIDE
$4,450
OCEANVIEW
$4,883
BALCONY
$7,167
SUITE
$10,018
Save (per person) 2,260
From (per person) 4,450
View Trip
11 Day Classic Panama Canal Passage with Viking Cruises
Cruise
 (7)

11 Days (10 Nights) Panama City to Fort Lauderdale
Operated By: Viking Cruises
Ship: Viking Mars
Departures: Nov 2025 to Dec 2026
Countries Visited: Panama, Costa Rica, Honduras, Belize (+2 more), Mexico, USA
Companion Fly Free
INSIDE
-
OCEANVIEW
-
BALCONY
$6,561
SUITE
$9,991
Save (per person) 144
From (per person) 6,561
View Trip
12 Day Caribbean Quest Voyage with Azamara Cruises
Cruise
 (1)

12 Days (11 Nights) Panama City to Miami
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 15 March 2026
Countries Visited: Panama, Colombia, Aruba, Bonaire (+3 more), Curacao, Dominican Republic, USA
INSIDE
$5,476
OCEANVIEW
$6,902
BALCONY
$8,506
SUITE
$11,674
From (per person) 5,476
View Trip
11 Day Captivating Panama Canal with Oceania Cruises
Cruise
 (3)

11 Days (10 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 02 April 2025
Countries Visited: Panama, Colombia, Aruba, Curacao (+3 more), Bonaire, Jamaica, USA
Exclusive Deal
INSIDE
-
OCEANVIEW
$9,049
BALCONY
-
SUITE
-
Save (per person) 2,071
From (per person) 9,049
View Trip
11 Day Canal & Coral Isles with Oceania Cruises
Cruise

11 Days (10 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 24 April 2026
Countries Visited: Panama, Colombia, Costa Rica, Honduras (+2 more), Mexico, USA
Exclusive Deal
INSIDE
$4,450
OCEANVIEW
$4,883
BALCONY
$7,167
SUITE
$9,876
Save (per person) 2,260
From (per person) 4,450
View Trip
12 Day The Panama Canal & Costa Rica with Tauck
Cruise

12 Days (11 Nights) Panama City to San Jose
Operated By: Tauck
Departure: 03 February 2026
Countries Visited: Panama, Costa Rica
From (per person) 14,190
View Trip
29 Day Canal To Coral Reefs with Regent Seven Seas
Cruise

29 Days (28 Nights) Panama City to Tahiti
Cruise Line: Regent Seven Seas
Ship: Seven Seas Splendor
Departure: 26 January 2027
Countries Visited: Panama, Costa Rica, Nicaragua, El Salvador (+4 more), Guatemala, Mexico, USA, French Polynesia
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$30,336
SUITE
$32,109
Save (per person) 8,714
From (per person) 30,336
View Trip
23 Day Journey To The Amazon with Regent Seven Seas
Cruise

23 Days (22 Nights) Panama City to Panama City
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 09 March 2027
Countries Visited: Panama, Aruba, Trinidad and Tobago, Brazil (+2 more), Grenada, Curacao
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$18,150
SUITE
$19,695
Save (per person) 7,840
From (per person) 18,150
View Trip
11 Day Classic Canal & Tropics with Oceania Cruises
Cruise

11 Days (10 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 04 April 2026
Countries Visited: Panama, Colombia, Curacao, Aruba (+3 more), Jamaica, Cayman Islands, USA
Exclusive Deal
INSIDE
$4,682
OCEANVIEW
$5,286
BALCONY
$7,543
SUITE
$10,701
Save (per person) 2,028
From (per person) 4,682
View Trip
38 Day Central America, Hawaiian Nights & Pacific Crossing with Seabourn
Cruise

38 Days (37 Nights) Panama City to Hong Kong
Cruise Line: Seabourn
Ship: Seabourn Encore
Departure: 12 December 2025
Countries Visited: Panama, Costa Rica, Mexico, USA (+3 more), Japan, Taiwan, China
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$19,241
SUITE
$37,358
From (per person) 19,241
View Trip
10 Day Wellness Retreat - Panama City to Valparaiso with Scenic
New ReleaseCruise

10 Days (9 Nights) Panama City to Santiago
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 26 October 2026
Countries Visited: Panama, Chile
Super EarlybirdReduced Single Supplement
INSIDE
-
OCEANVIEW
-
BALCONY
$8,343
SUITE
$10,778
Save (per person) 3,052
From (per person) 8,343
View Trip
30 Day Pacific Crossing & Treasures Of Japan with Seabourn
Cruise

30 Days (29 Nights) Panama City to Tokyo
Cruise Line: Seabourn
Ship: Seabourn Encore
Departure: 12 December 2025
Countries Visited: Panama, Costa Rica, Mexico, USA (+1 more), Japan
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$12,598
SUITE
$24,082
From (per person) 12,598
View Trip
11 Day Tropical Tastes Of The Riviera with Regent Seven Seas
Cruise

11 Days (10 Nights) Panama City to Los Angeles
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 15 January 2026
Countries Visited: Panama, Costa Rica, Nicaragua, Mexico (+1 more), USA
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$10,509
SUITE
$11,103
Save (per person) 5,841
From (per person) 10,509
View Trip
18 Day Costa Rica, Mexico & Hawaiian Nights with Seabourn
Cruise

18 Days (17 Nights) Panama City to Honolulu
Cruise Line: Seabourn
Ship: Seabourn Encore
Departure: 12 December 2025
Countries Visited: Panama, Costa Rica, Mexico, USA
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$8,826
SUITE
$16,152
From (per person) 8,826
View Trip
12 Day Panama Canal & the Alluring Islands of the Caribbean with Scenic
New ReleaseCruise

12 Days (11 Nights) Panama City to Bridgetown
Cruise Line: Scenic
Ship: Scenic Eclipse II
Departure: 13 April 2026
Countries Visited: Panama, Colombia, Aruba, Curacao (+2 more), Saint Vincent, Barbados
Super EarlybirdReduced Single Supplement
INSIDE
-
OCEANVIEW
-
BALCONY
$13,172
SUITE
$14,568
Save (per person) 3,603
From (per person) 13,172
View Trip
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