Home > Cruises > Central America Cruises > Panama > Cruises From Panama City

Cruises From Panama City

Choose from 19 unique cruises starting in Panama City, and travelling to Bridgetown, Fort Lauderdale, Galveston, Los Angeles, Miami and more. December is the most popular month to join a cruise from Panama City and you can select from 22 departures available from eight leading cruise lines.
Filter Results
Departures
Show More...
Duration
8 Days
14 Days
Countries Visited
End City
Ship Features
Operators
Show More...
Price
$2,200pp
$15,750pp
Countries
Show More...
Filter Results
19 Cruises (22 Cruise Departures)
11 Day Classic Panama Canal Passage with Viking Cruises
Cruise
 (4)

11 Days (10 Nights) Panama City to Fort Lauderdale
Cruise Line: Viking Cruises
Ship: Viking Mars
Departures: Oct 2024 to Dec 2025
Countries Visited: Panama, Costa Rica, Honduras, Belize (+2 more), Mexico, USA
Discover More Sale
INSIDE
-
OCEANVIEW
-
BALCONY
$5,638
SUITE
$8,905
Save 2,461
From 5,638
View Trip
12 Day Classic Panama Canal with Oceania Cruises
Cruise
 (2)

12 Days (11 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 18 February 2025
Countries Visited: Panama, Colombia, Aruba, Curacao (+4 more), Bonaire, Jamaica, Bahamas, USA
Exclusive Deal
INSIDE
$5,931
OCEANVIEW
$6,386
BALCONY
$8,831
SUITE
-
Save 2,039
From 5,931
View Trip
11 Day Captivating Panama Canal with Oceania Cruises
Cruise
 (2)

11 Days (10 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 02 April 2025
Countries Visited: Panama, Colombia, Aruba, Curacao (+3 more), Bonaire, Jamaica, USA
Exclusive Deal
INSIDE
$5,147
OCEANVIEW
$5,533
BALCONY
$7,751
SUITE
$10,285
Save 2,033
From 5,147
View Trip
12 Day Caribbean Quest Voyage with Azamara Cruises
Cruise
 (1)

12 Days (11 Nights) Panama City to Miami
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 15 March 2026
Countries Visited: Panama, Colombia, Aruba, Bonaire (+3 more), Curacao, Dominican Republic, USA
INSIDE
$3,963
OCEANVIEW
$4,912
BALCONY
$5,832
SUITE
$6,752
From 3,963
View Trip
10 Day Panama Canal Voyage with Azamara Cruises
Cruise
 (1)

10 Days (9 Nights) Panama City to Miami
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 13 December 2024
Countries Visited: Panama, Costa Rica, Honduras, Guatemala (+2 more), Mexico, USA
Circle Club Voyage
INSIDE
$3,311
OCEANVIEW
$3,492
BALCONY
$4,268
SUITE
$5,820
From 3,311
View Trip
11 Day Panama Canal - Panama City with Norwegian Cruise Line
Cruise

11 Days (10 Nights) Panama City to Miami
Ship: Norwegian Jade
Departure: 10 November 2025
Countries Visited: Panama, Colombia, Jamaica, Cayman Islands (+4 more), Honduras, Belize, Mexico, USA
INSIDE
$2,984
OCEANVIEW
$3,443
BALCONY
$4,666
SUITE
$5,049
From 2,984
View Trip
11 Day Tropical Tastes Of The Riviera with Regent Seven Seas
Cruise

11 Days (10 Nights) Panama City to Los Angeles
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 15 January 2026
Countries Visited: Panama, Costa Rica, Nicaragua, Mexico (+1 more), USA
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$9,618
SUITE
$10,143
Save 6,132
From 9,618
View Trip
12 Day Panama City to Los Angeles with Silversea
Cruise

12 Days (11 Nights) Panama City to Los Angeles
Cruise Line: Silversea
Ship: Silver Shadow
Departure: 24 December 2024
Countries Visited: Panama, Costa Rica, Mexico, USA
Port-to-PortExclusive Solo Offer
INSIDE
-
OCEANVIEW
$6,781
BALCONY
$9,256
SUITE
-
Save 819
From 6,781
View Trip
12 Day Panama Canal - Panama City with Norwegian Cruise Line
Cruise

12 Days (11 Nights) Panama City to Miami
Ship: Norwegian Jade
Departure: 16 February 2026
Countries Visited: Panama, Colombia, Aruba, Saint Lucia (+4 more), Saint Kitts and Nevis, Virgin Islands, Dominican Republic, USA
INSIDE
$3,085
OCEANVIEW
$3,620
BALCONY
$5,118
SUITE
$5,502
From 3,085
View Trip
12 Day The Panama Canal & Costa Rica - Westbound with Tauck
Cruise

12 Days (11 Nights) Panama City to San Jose
Operated By: Tauck
Departure: 18 January 2025
Trip Styles: Group, Cruise
Countries Visited: Panama, Costa Rica
From 14,250
View Trip
12 Day Panama Canal & the Alluring Islands of the Caribbean with Scenic
New ReleaseCruise

12 Days (11 Nights) Panama City to Bridgetown
Cruise Line: Scenic
Ship: Scenic Eclipse II
Departure: 13 April 2026
Countries Visited: Panama, Colombia, Aruba, Curacao (+2 more), Saint Vincent, Barbados
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$11,727
SUITE
$14,538
Save 3,618
From 11,727
View Trip
14 Day Panama Canal - Panama City with Norwegian Cruise Line
Cruise

14 Days (13 Nights) Panama City to New York
Ship: Norwegian Jade
Departure: 22 December 2025
Countries Visited: Panama, Colombia, Aruba, Curacao (+5 more), Saint Lucia, Saint Kitts and Nevis, Virgin Islands, Dominican Republic, USA
INSIDE
$4,305
OCEANVIEW
$5,071
BALCONY
$6,982
SUITE
$8,129
From 4,305
View Trip
11 Day Canal & Coral Isles with Oceania Cruises
Cruise

11 Days (10 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 24 April 2026
Countries Visited: Panama, Colombia, Costa Rica, Honduras (+2 more), Mexico, USA
Exclusive Deal
INSIDE
$5,026
OCEANVIEW
$5,482
BALCONY
$7,927
SUITE
$10,927
Save 2,034
From 5,026
View Trip
10 Day Panama Canal - Panama City with Norwegian Cruise Line
Cruise

10 Days (9 Nights) Panama City to Miami
Ship: Norwegian Gem
Departure: 11 December 2024
Countries Visited: Panama, Costa Rica, Jamaica, Cayman Islands (+3 more), Mexico, Bahamas, USA
INSIDE
$2,285
OCEANVIEW
$2,560
BALCONY
$3,629
SUITE
$3,813
From 2,285
View Trip
12 Day Panama Canal - Panama City with Norwegian Cruise Line
Cruise

12 Days (11 Nights) Panama City to Galveston
Ship: Norwegian Jade
Departure: 26 January 2026
Countries Visited: Panama, Colombia, Jamaica, Cayman Islands (+4 more), Honduras, Belize, Mexico, USA
Exclusive Solo Offer
INSIDE
$3,124
OCEANVIEW
$3,659
BALCONY
$5,036
SUITE
$5,541
From 3,124
View Trip
11 Day Panama Canal Repositioning Cruise with Norwegian Cruise Line
Cruise

11 Days (10 Nights) Panama City to Tampa
Ship: Norwegian Jade
Departure: 19 January 2025
Countries Visited: Panama, Colombia, Jamaica, Cayman Islands (+4 more), Honduras, Belize, Mexico, USA
INSIDE
$2,504
OCEANVIEW
$2,825
BALCONY
$4,217
SUITE
$4,492
From 2,504
View Trip
10 Day Wellness Retreat - Panama City to Valparaiso with Scenic
New ReleaseCruise

10 Days (9 Nights) Panama City to Santiago
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 26 October 2026
Countries Visited: Panama, Chile
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$8,311
SUITE
$10,746
Save 3,084
From 8,311
View Trip
11 Day Classic Canal & Tropics with Oceania Cruises
Cruise

11 Days (10 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 04 April 2026
Countries Visited: Panama, Colombia, Curacao, Aruba (+3 more), Jamaica, Cayman Islands, USA
Exclusive Deal
INSIDE
$5,026
OCEANVIEW
$5,482
BALCONY
$7,927
SUITE
$10,927
Save 2,034
From 5,026
View Trip
8 Day Panama City to Fort Lauderdale with Silversea
Cruise

8 Days (7 Nights) Panama City to Fort Lauderdale
Cruise Line: Silversea
Ship: Silver Shadow
Departure: 20 May 2025
Countries Visited: Panama, Colombia, USA
Port-to-PortExclusive Solo Offer
INSIDE
-
OCEANVIEW
$5,395
BALCONY
$6,286
SUITE
-
Save 805
From 5,395
View Trip
Results: 19 results

No Results found. Try changing your search filters.




Cruises found! Scroll up to view

South & Central America Cruises

Central America Cruises South America Cruises Mexico Cruises Galapagos Cruises Bermunda Cruises Bahamas Cruises Caribbean Cruises Amazon Cruises Patagonia Cruises Cape Horn Cruises Falkland Island Cruises Panama Cruises

Travel Styles

Luxury Cruises

Trip Lengths

10 Day

Departure Months

October 2024 December 2024 January 2025 February 2025 April 2025 May 2025 November 2025 December 2025 January 2026 February 2026 March 2026 April 2026 October 2026

Cities

Panama City Santiago

Routes

Miami to Panama City Panama City to Miami

Country Routes

Panama to USA USA to Panama

Cruise Lines Exploring South & Central America

Azamara South America Cruises Celebrity Central America Cruises Cunard Central America Cruises Hurtigruten South America Cruises MSC South America Cruises NCL Central America Cruises Oceania South America Cruises Ponant South America Cruises Princess South America Cruises Regent Seven Seas South America Cruises Royal Caribbean Central America Cruises Seabourn South America Cruises Silversea South America Cruises Viking South America Cruises Viking Central America Cruises

Central America Tours

All Central America Tours Belize Tours Costa Rica Tours Guatemala Tours Mexico Tours Panama Tours

© 2010-2024. Global Journeys. You're viewing our site in Australian dollars.

    

About Us | View Your Booking | Terms & Conditions | Site Map | We're Hiring!

Global Journeys Pty Ltd. Member of The Australian Travel Industry Association (AITA) & ATAS Travel Accredited (No. A11351).

Travel Industry Associations