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Cruises from Panama to USA

Are you looking for a cruise from Panama to USA? April, February and March are the most popular months to cruise between Panama and USA and there are 23 departures available from eight of the world's leading cruise lines.
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11 Days
37 Days
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18 Cruises (23 Cruise Departures)
11 Day Canal & Caribbean Discovery with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 27 January 2026
Countries Visited: Panama, Colombia, Bonaire, Curacao (+3 more), Aruba, Jamaica, USA
Exclusive Deal
INSIDE
$4,450
OCEANVIEW
$4,883
BALCONY
$7,167
SUITE
$10,018
Save (per person) 2,260
From (per person) 4,450
View Trip
20 Day Southern America & Panama Canal Cruise: Lima, Panama City & Cozumel with Azamara Cruises
Cruise
 (1)

20 Days (19 Nights) Santiago to Miami
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 10 March 2027
Countries Visited: Chile, Peru, Panama, Costa Rica (+3 more), Colombia, Mexico, USA
INSIDE
$7,355
OCEANVIEW
$8,177
BALCONY
$10,592
SUITE
$16,117
From (per person) 7,355
View Trip
11 Day Classic Panama Canal Passage with Viking Cruises
Cruise
 (7)

11 Days (10 Nights) Panama City to Fort Lauderdale
Operated By: Viking Cruises
Ship: Viking Mars
Departures: Nov 2025 to Dec 2026
Countries Visited: Panama, Costa Rica, Honduras, Belize (+2 more), Mexico, USA
Companion Fly Free
INSIDE
-
OCEANVIEW
-
BALCONY
$6,561
SUITE
$9,991
Save (per person) 144
From (per person) 6,561
View Trip
12 Day Caribbean Quest Voyage with Azamara Cruises
Cruise
 (1)

12 Days (11 Nights) Panama City to Miami
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 15 March 2026
Countries Visited: Panama, Colombia, Aruba, Bonaire (+3 more), Curacao, Dominican Republic, USA
INSIDE
$5,476
OCEANVIEW
$6,902
BALCONY
$8,506
SUITE
$11,674
From (per person) 5,476
View Trip
18 Day Panama & Scenic South America with Viking Cruises
Cruise
 (1)

18 Days (17 Nights) Santiago to Fort Lauderdale
Operated By: Viking Cruises
Ships: Viking Octantis, Viking Polaris
Departures: Mar 2025 to Mar 2027
Countries Visited: Chile, Peru, Ecuador, Panama (+2 more), Mexico, USA
Companion Fly Free
INSIDE
-
OCEANVIEW
-
BALCONY
$15,871
SUITE
$22,731
Save (per person) 424
From (per person) 15,871
View Trip
11 Day Captivating Panama Canal with Oceania Cruises
Cruise
 (3)

11 Days (10 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 02 April 2025
Countries Visited: Panama, Colombia, Aruba, Curacao (+3 more), Bonaire, Jamaica, USA
Exclusive Deal
INSIDE
-
OCEANVIEW
$9,049
BALCONY
-
SUITE
-
Save (per person) 2,071
From (per person) 9,049
View Trip
17 Day Inca & Panama Canal Discovery: Lima Overnight with Holland America
Cruise
 (2)

17 Days (16 Nights) Santiago to Fort Lauderdale
Cruise Line: Holland America
Ship: Oosterdam
Departure: 24 March 2027
Countries Visited: Chile, Peru, Ecuador, Panama (+2 more), Cayman Islands, USA
Exclusive Deal
INSIDE
$4,099
OCEANVIEW
$4,544
BALCONY
$5,584
SUITE
$7,861
From (per person) 4,099
View Trip
34 Day San Antonio To Southampton with Cunard
Cruise

34 Days (33 Nights) Santiago to London
Cruise Line: Cunard
Ship: Queen Anne
Departure: 28 February 2027
Countries Visited: Chile, Peru, Ecuador, Panama (+4 more), Aruba, USA, Portugal, England
Exclusive Deal
INSIDE
$9,317
OCEANVIEW
$13,871
BALCONY
$15,653
SUITE
$28,226
From (per person) 9,317
View Trip
11 Day Canal & Coral Isles with Oceania Cruises
Cruise

11 Days (10 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 24 April 2026
Countries Visited: Panama, Colombia, Costa Rica, Honduras (+2 more), Mexico, USA
Exclusive Deal
INSIDE
$4,450
OCEANVIEW
$4,883
BALCONY
$7,167
SUITE
$9,876
Save (per person) 2,260
From (per person) 4,450
View Trip
32 Day San Antonio To Southampton with Cunard
Cruise

32 Days (31 Nights) Santiago to London
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 25 February 2025
Countries Visited: Chile, Peru, Ecuador, Panama (+6 more), Aruba, Bahamas, USA, Bermuda, Portugal, England
Exclusive Deal
INSIDE
$7,237
OCEANVIEW
$8,910
BALCONY
$12,870
SUITE
$25,552
From (per person) 7,237
View Trip
11 Day Classic Canal & Tropics with Oceania Cruises
Cruise

11 Days (10 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 04 April 2026
Countries Visited: Panama, Colombia, Curacao, Aruba (+3 more), Jamaica, Cayman Islands, USA
Exclusive Deal
INSIDE
$4,682
OCEANVIEW
$5,286
BALCONY
$7,543
SUITE
$10,701
Save (per person) 2,028
From (per person) 4,682
View Trip
20 Day San Antonio To Fort Lauderdale with Cunard
Cruise

20 Days (19 Nights) Santiago to Fort Lauderdale
Cruise Line: Cunard
Ship: Queen Anne
Departure: 28 February 2027
Countries Visited: Chile, Peru, Ecuador, Panama (+2 more), Aruba, USA
Exclusive Deal
INSIDE
$6,738
OCEANVIEW
$9,906
BALCONY
$11,193
SUITE
$19,806
From (per person) 6,738
View Trip
11 Day Panama Canal Westward Cruise with Royal Caribbean
Cruise

11 Days (10 Nights) Colon to Los Angeles
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 25 April 2026
Countries Visited: Panama, Costa Rica, Mexico, USA
Exclusive DealExclusive Solo Offer
INSIDE
$2,033
OCEANVIEW
$2,507
BALCONY
$3,079
SUITE
$4,380
Save (per person) 913
From (per person) 2,033
View Trip
18 Day San Antonio To Fort Lauderdale with Cunard
Cruise

18 Days (17 Nights) Santiago to Fort Lauderdale
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 25 February 2025
Countries Visited: Chile, Peru, Ecuador, Panama (+3 more), Aruba, Bahamas, USA
Exclusive Deal
INSIDE
$5,252
OCEANVIEW
$6,192
BALCONY
$8,321
SUITE
-
From (per person) 5,252
View Trip
13 Day Pacific Pathways with Oceania Cruises
Cruise

13 Days (12 Nights) Colon to Los Angeles
Cruise Line: Oceania Cruises
Ship: Oceania Regatta
Departure: 14 November 2025
Countries Visited: Panama, Costa Rica, Nicaragua, Guatemala (+2 more), Mexico, USA
Mutiple Deals Available
INSIDE
$3,081
OCEANVIEW
$3,457
BALCONY
$5,025
SUITE
$7,051
Save (per person) 4,539
From (per person) 3,081
View Trip
11 Day Tropical Tastes Of The Riviera with Regent Seven Seas
Cruise

11 Days (10 Nights) Panama City to Los Angeles
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 15 January 2026
Countries Visited: Panama, Costa Rica, Nicaragua, Mexico (+1 more), USA
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$10,509
SUITE
$11,103
Save (per person) 5,841
From (per person) 10,509
View Trip
18 Day Costa Rica, Mexico & Hawaiian Nights with Seabourn
Cruise

18 Days (17 Nights) Panama City to Honolulu
Cruise Line: Seabourn
Ship: Seabourn Encore
Departure: 12 December 2025
Countries Visited: Panama, Costa Rica, Mexico, USA
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$8,826
SUITE
$16,152
From (per person) 8,826
View Trip
37 Day San Antonio To Hamburg with Cunard
Cruise

37 Days (36 Nights) Santiago to Hamburg
Cruise Line: Cunard
Ship: Queen Anne
Departure: 28 February 2027
Countries Visited: Chile, Peru, Ecuador, Panama (+6 more), Aruba, USA, Portugal, England, Belgium, Germany
Exclusive Deal
INSIDE
$10,407
OCEANVIEW
$14,862
BALCONY
$17,139
SUITE
$31,494
From (per person) 10,407
View Trip
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