Home > Cruises > Central America Cruises > Panama Cruises

Panama Cruises

Are you looking for a cruise to Panama? Choose from 83 unique cruise itineraries to Panama, departing from Cartagena, Colon, Fort Lauderdale, London, Los Angeles and more. January is the most popular month to cruise to Panama and we have over 128 departures available from fifteen of the world's leading cruise lines.
Filter Results
Departures
Show More...
Duration
2 Days
30 Days
Countries Visited
Start & End Cities
Ship Size
Ship Features
Operators
Show More...
Price
$100pp
$41,200pp
Countries
Show More...
Filter Results
83 Cruises (128 Cruise Departures)
11 Day Secrets of Central America with Ponant
Cruise

11 Days (10 Nights) Colon to Puntarenas
Cruise Line: Ponant
Ship: Le Bellot
Departure: 23 February 2025
Countries Visited: Panama, Costa Rica
Exclusive Savings
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$32,286
Save (per person) 644
From (per person) 32,286
View Trip
2 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

2 Days (1 Nights) Colon to Cartagena
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 18 April 2026
Countries Visited: Panama, Colombia
Exclusive DealLatest Offer
INSIDE
$170
OCEANVIEW
$229
BALCONY
$240
SUITE
$353
Save (per person) 195
From (per person) 170
View Trip
12 Day The Panama Canal & Costa Rica with Tauck
Cruise

12 Days (11 Nights) Panama City to San Jose
Operated By: Tauck
Departure: 03 February 2026
Countries Visited: Panama, Costa Rica
From (per person) 14,190
View Trip
8 Day Central America Jewels & Panama Canal with Ponant
Cruise

8 Days (7 Nights) Puntarenas to Colon
Cruise Line: Ponant
Ship: Le Dumont d’Urville
Departures: Dec 2025 to Jan 2026
Countries Visited: Costa Rica, Panama
Exclusive Savings
INSIDE
-
OCEANVIEW
-
BALCONY
$6,959
SUITE
$11,908
Save (per person) 152
From (per person) 6,959
View Trip
8 Day Panama and Costa Rica by Sea: The Natural Wonders of Central America – with Smithsonian Journeys with Ponant
Cruise

8 Days (7 Nights) Puntarenas to Colon
Cruise Line: Ponant
Ship: Le Champlain
Departure: 26 February 2026
Countries Visited: Costa Rica, Panama
Exclusive Savings
INSIDE
-
OCEANVIEW
-
BALCONY
$8,203
SUITE
$13,809
Save (per person) 157
From (per person) 8,203
View Trip
11 Day Secrets of Central America with Ponant
Cruise

11 Days (10 Nights) Puntarenas to Colon
Cruise Line: Ponant
Ship: Le Champlain
Departure: 15 March 2026
Countries Visited: Costa Rica, Panama
Exclusive Savings
INSIDE
-
OCEANVIEW
-
BALCONY
$12,402
SUITE
$19,174
Save (per person) 238
From (per person) 12,402
View Trip
10 Day Wellness Retreat - Panama City to Valparaiso with Scenic
New ReleaseCruise

10 Days (9 Nights) Panama City to Santiago
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 26 October 2026
Countries Visited: Panama, Chile
Super EarlybirdReduced Single Supplement
INSIDE
-
OCEANVIEW
-
BALCONY
$8,343
SUITE
$10,778
Save (per person) 3,052
From (per person) 8,343
View Trip
8 Day Panama and Costa Rica by Sea: The Natural Wonders of Central America – with Smithsonian Journeys with Ponant
Cruise

8 Days (7 Nights) Colon to Puntarenas
Cruise Line: Ponant
Ship: Le Champlain
Departure: 19 February 2026
Countries Visited: Panama, Costa Rica
Exclusive Savings
INSIDE
-
OCEANVIEW
-
BALCONY
$8,174
SUITE
$13,779
Save (per person) 156
From (per person) 8,174
View Trip
11 Day Secrets of Central America with Ponant
Cruise

11 Days (10 Nights) Colon to Puntarenas
Cruise Line: Ponant
Ship: Le Champlain
Departures: Jan 2026 to Mar 2026
Countries Visited: Panama, Costa Rica
Exclusive Savings
INSIDE
-
OCEANVIEW
-
BALCONY
$12,402
SUITE
$19,174
Save (per person) 280
From (per person) 12,402
View Trip
12 Day The Panama Canal & Costa Rica with Tauck
Cruise

12 Days (11 Nights) San Jose to Panama City
Operated By: Tauck
Departures: Jan 2026 to Feb 2026
Countries Visited: Costa Rica, Panama
From (per person) 13,590
View Trip
8 Day Central America Jewels & Panama Canal with Ponant
Cruise

8 Days (7 Nights) Colon to Puntarenas
Cruise Line: Ponant
Ship: Le Dumont d’Urville
Departures: Dec 2025 to Jan 2026
Countries Visited: Panama, Costa Rica
Exclusive Savings
INSIDE
-
OCEANVIEW
-
BALCONY
$6,959
SUITE
$11,908
Save (per person) 147
From (per person) 6,959
View Trip
14 Day Chile, Peru & Panama Voyage with Azamara Cruises
Cruise
 (1)

14 Days (13 Nights) San Antonio to Panama City
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 02 March 2026
Countries Visited: Chile, Peru, Panama
Circle Club Voyage
INSIDE
$7,658
OCEANVIEW
$8,390
BALCONY
$10,638
SUITE
$13,875
From (per person) 7,658
View Trip
20 Day Treasures of French Polynesia & the Marquesas Islands with Scenic
New ReleaseCruise

20 Days (19 Nights) Papeete to Panama City
Cruise Line: Scenic
Ship: Scenic Eclipse II
Departure: 25 March 2026
Countries Visited: French Polynesia, Costa Rica, Panama
Super EarlybirdReduced Single Supplement
INSIDE
-
OCEANVIEW
-
BALCONY
$15,981
SUITE
$18,842
Save (per person) 6,634
From (per person) 15,981
View Trip
8 Day Natural Sanctuaries & Heritage of the Caribbean with Ponant
Cruise

8 Days (7 Nights) Willemstad to Colon
Cruise Line: Ponant
Ship: Le Champlain
Departure: 26 November 2025
Countries Visited: Curacao, Colombia, Panama
Exclusive Solo Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$6,126
SUITE
$9,810
Save (per person) 114
From (per person) 6,126
View Trip
11 Day Pristine islands of the Bahamas & the Panama Canal with Scenic
New ReleaseCruise

11 Days (10 Nights) Nassau to Panama City
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 16 October 2026
Countries Visited: Bahamas, Colombia, Panama
Super EarlybirdReduced Single Supplement
INSIDE
-
OCEANVIEW
-
BALCONY
$10,468
SUITE
$13,240
Save (per person) 3,577
From (per person) 10,468
View Trip
16 Day New York To Los Angeles with Cunard
Cruise
 (3)

16 Days (15 Nights) New York to Los Angeles
Cruise Line: Cunard
Ship: Queen Mary 2
Departure: 19 January 2026
Countries Visited: USA, Curacao, Panama, Mexico
Exclusive Deal
INSIDE
$4,905
OCEANVIEW
$7,429
BALCONY
$7,726
SUITE
$15,300
From (per person) 4,905
View Trip
19 Day New York To San Francisco with Cunard
Cruise
 (3)

19 Days (18 Nights) New York to San Francisco
Cruise Line: Cunard
Ship: Queen Mary 2
Departure: 19 January 2026
Countries Visited: USA, Curacao, Panama, Mexico
Exclusive Deal
INSIDE
$5,896
OCEANVIEW
$9,212
BALCONY
$9,361
SUITE
-
From (per person) 5,896
View Trip
22 Day America's Historic Journey to Panama with Scenic
New ReleaseCruise

22 Days (21 Nights) New York to Panama City
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 05 October 2026
Countries Visited: USA, Bahamas, Colombia, Panama
Super Earlybird
INSIDE
-
OCEANVIEW
-
BALCONY
$30,825
SUITE
$39,428
Save (per person) 5,610
From (per person) 30,825
View Trip
7 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

7 Days (6 Nights) Cartagena to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 19 April 2026
Countries Visited: Colombia, Curacao, Aruba, Panama
Exclusive Deal
INSIDE
$1,575
OCEANVIEW
$1,724
BALCONY
$2,074
SUITE
$3,158
Save (per person) 930
From (per person) 1,575
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Jan 2026 to Mar 2026
Countries Visited: Colombia, Aruba, Curacao, Panama
Exclusive DealExclusive Solo Offer
INSIDE
$1,390
OCEANVIEW
$1,533
BALCONY
$1,794
SUITE
$2,464
Save (per person) 1,013
From (per person) 1,390
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Nov 2025 to Nov 2025
Countries Visited: Panama, Colombia, Bonaire, Curacao
Exclusive Deal
INSIDE
$1,405
OCEANVIEW
$1,404
BALCONY
$1,370
SUITE
$2,047
Save (per person) 935
From (per person) 1,370
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Oct 2025 to Apr 2026
Countries Visited: Panama, Colombia, Curacao, Aruba
Exclusive Deal
INSIDE
$1,251
OCEANVIEW
$1,394
BALCONY
$1,534
SUITE
$1,974
Save (per person) 1,010
From (per person) 1,251
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Jan 2026 to Feb 2026
Countries Visited: Panama, Colombia, Bonaire, Aruba
Exclusive Deal
INSIDE
$1,248
OCEANVIEW
$1,283
BALCONY
$1,493
SUITE
$2,320
Save (per person) 831
From (per person) 1,248
View Trip
11 Day Panama Canal Westward Cruise with Royal Caribbean
Cruise

11 Days (10 Nights) Colon to Los Angeles
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 25 April 2026
Countries Visited: Panama, Costa Rica, Mexico, USA
Exclusive DealExclusive Solo Offer
INSIDE
$2,033
OCEANVIEW
$2,507
BALCONY
$3,079
SUITE
$4,380
Save (per person) 913
From (per person) 2,033
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Nov 2025 to Nov 2025
Countries Visited: Colombia, Bonaire, Curacao, Panama
Exclusive Deal
INSIDE
$1,542
OCEANVIEW
$1,620
BALCONY
$1,669
SUITE
$2,114
Save (per person) 1,013
From (per person) 1,542
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Oct 2025 to Apr 2026
Countries Visited: Colombia, Curacao, Aruba, Panama
Exclusive DealExclusive Solo Offer
INSIDE
$1,379
OCEANVIEW
$1,523
BALCONY
$1,783
SUITE
$2,642
Save (per person) 1,196
From (per person) 1,379
View Trip
8 Day Southern Caribbean Holiday with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 20 December 2025
Countries Visited: Panama, Colombia, Curacao, Aruba
Exclusive Deal
INSIDE
$1,671
OCEANVIEW
$1,729
BALCONY
$1,890
SUITE
$2,696
Save (per person) 966
From (per person) 1,671
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 18 January 2026
Countries Visited: Colombia, Bonaire, Aruba, Panama
Exclusive Deal
INSIDE
$1,747
OCEANVIEW
$1,810
BALCONY
$1,863
SUITE
$2,386
Save (per person) 1,001
From (per person) 1,747
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Oct 2025 to Nov 2025
Countries Visited: Colombia, Aruba, Curacao, Panama
Exclusive DealExclusive Solo Offer
INSIDE
$1,780
OCEANVIEW
$1,780
BALCONY
$1,874
SUITE
$2,260
Save (per person) 1,166
From (per person) 1,780
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Nov 2025 to Apr 2026
Countries Visited: Colombia, Aruba, Curacao, Panama
Exclusive DealExclusive Solo Offer
INSIDE
$1,379
OCEANVIEW
$1,523
BALCONY
$1,747
SUITE
$2,335
Save (per person) 979
From (per person) 1,379
View Trip
Results: 1-30 of 83

No Results found. Try changing your search filters.




Cruises found! Scroll up to view

South & Central America Cruises

Central America Cruises South America Cruises Mexico Cruises Galapagos Cruises Bermunda Cruises Bahamas Cruises Caribbean Cruises Amazon Cruises Patagonia Cruises Cape Horn Cruises Falkland Island Cruises Panama Cruises

Travel Styles

Luxury Cruises

Trip Lengths

3 Week

Departure Months

February 2025 March 2025 April 2025 May 2025 September 2025 October 2025 November 2025 December 2025 January 2026 February 2026 March 2026 April 2026 May 2026 September 2026 October 2026 November 2026 December 2026 January 2027 February 2027 March 2027 April 2027

Cities

Colon Panama City Santiago

Routes

Colon to Colon Miami to Panama City Panama City to Miami

Country Routes

Panama to USA USA to Panama

Cruise Lines Exploring South & Central America

Azamara South America Cruises Celebrity Central America Cruises Cunard Central America Cruises HX Hurtigruten South America Expeditions MSC South America Cruises NCL Central America Cruises Oceania South America Cruises Ponant South America Cruises Ponant Central America Cruises Princess South America Cruises Regent Seven Seas South America Cruises Royal Caribbean Central America Cruises Seabourn South America Cruises Silversea South America Cruises Viking Central America Cruises Viking South America Cruises

Central America Tours

All Central America Tours Belize Tours Costa Rica Tours Guatemala Tours Mexico Tours Panama Tours

© 2010-2025. Global Journeys. You're viewing our site in Australian dollars.

    

About Us | View Your Booking | Terms & Conditions | Site Map

Global Journeys Pty Ltd. Accredited Member of The Australian Travel Industry Association (AITA). No. A11351.

Travel Industry Associations