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Royal Caribbean Cruises from San Diego

Start your journey from San Diego with 15 unique Royal Caribbean cruise itineraries to choose from. March is the most popular month to begin your cruise from San Diego and Royal Caribbean have 46 trips departing this season.
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17 Days
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15 Cruises (46 Cruise Departures)
8 Day Ensenada, Cabo & La Paz Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) San Diego to San Diego
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Oct 2026 to Mar 2027
Countries Visited: USA, Mexico
Exclusive Deal
INSIDE
$1,146
OCEANVIEW
$1,471
BALCONY
$1,654
SUITE
$2,757
Save (per person) 753
From (per person) 1,146
View Trip
8 Day Cabo Overnight, Catalina & Ensenada with Royal Caribbean
Cruise

8 Days (7 Nights) San Diego to San Diego
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 13 December 2026
Countries Visited: USA, Mexico
Exclusive Deal
INSIDE
$1,198
OCEANVIEW
$1,522
BALCONY
$1,753
SUITE
$3,410
Save (per person) 681
From (per person) 1,198
View Trip
14 Day Panama Canal Eastward Cruise with Royal Caribbean
Cruise

14 Days (13 Nights) San Diego to Miami
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 19 September 2025
Countries Visited: USA, Mexico, Costa Rica, Panama (+1 more), Colombia
Exclusive DealExclusive Solo Offer
INSIDE
$2,353
OCEANVIEW
$2,858
BALCONY
-
SUITE
-
Save (per person) 980
From (per person) 2,353
View Trip
5 Day Catalina & Ensenada Cruise with Royal Caribbean
Cruise

5 Days (4 Nights) San Diego to San Diego
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Oct 2026 to Apr 2027
Countries Visited: USA, Mexico
Exclusive Deal
INSIDE
$754
OCEANVIEW
$908
BALCONY
$1,009
SUITE
$1,230
Save (per person) 442
From (per person) 754
View Trip
8 Day Cabo, Mazatlan & La Paz Holiday with Royal Caribbean
Cruise

8 Days (7 Nights) San Diego to San Diego
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Nov 2026 to Dec 2026
Countries Visited: USA, Mexico
Exclusive Deal
INSIDE
$1,481
OCEANVIEW
$1,820
BALCONY
$1,974
SUITE
$3,801
Save (per person) 932
From (per person) 1,481
View Trip
8 Day Ensenada, Cabo & Mazatlan with Royal Caribbean
Cruise

8 Days (7 Nights) San Diego to San Diego
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Nov 2026 to Feb 2027
Countries Visited: USA, Mexico
Exclusive Deal
INSIDE
$1,205
OCEANVIEW
$1,511
BALCONY
$1,663
SUITE
$3,572
Save (per person) 696
From (per person) 1,205
View Trip
8 Day Cabo, Mazatlan & La Paz Holiday with Royal Caribbean
Cruise

8 Days (7 Nights) San Diego to San Diego
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 27 December 2026
Countries Visited: USA, Mexico
Exclusive Deal
INSIDE
$1,854
OCEANVIEW
$2,071
BALCONY
$2,548
SUITE
$4,900
Save (per person) 989
From (per person) 1,854
View Trip
17 Day Panama Canal Cruise with Royal Caribbean
Cruise

17 Days (16 Nights) San Diego to Fort Lauderdale
Cruise Line: Royal Caribbean
Ship: Radiance of the Seas
Departure: 04 October 2025
Countries Visited: USA, Mexico, Guatemala, Costa Rica (+3 more), Panama, Colombia, Cayman Islands
Exclusive Deal
INSIDE
$3,278
OCEANVIEW
-
BALCONY
$7,259
SUITE
-
Save (per person) 1,373
From (per person) 3,278
View Trip
8 Day Ensenada, Cabo & La Paz Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) San Diego to San Diego
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Oct 2026 to Nov 2026
Countries Visited: USA, Mexico
Exclusive Deal
INSIDE
$1,176
OCEANVIEW
$1,501
BALCONY
$1,731
SUITE
$2,942
Save (per person) 681
From (per person) 1,176
View Trip
8 Day Cabo, Mazatlan & La Paz with Royal Caribbean
Cruise

8 Days (7 Nights) San Diego to San Diego
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 28 January 2027
Countries Visited: USA, Mexico
Exclusive Deal
INSIDE
$1,176
OCEANVIEW
$1,500
BALCONY
$1,654
SUITE
$3,743
Save (per person) 681
From (per person) 1,176
View Trip
5 Day Catalina & Ensenada Cruise with Royal Caribbean
Cruise

5 Days (4 Nights) San Diego to San Diego
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 07 March 2027
Countries Visited: USA, Mexico
Exclusive Deal
INSIDE
$814
OCEANVIEW
$968
BALCONY
$1,085
SUITE
$1,383
Save (per person) 406
From (per person) 814
View Trip
3 Day Ensenada Cruise with Royal Caribbean
Cruise

3 Days (2 Nights) San Diego to San Diego
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 02 October 2026
Countries Visited: USA, Mexico
Exclusive Deal
INSIDE
$475
OCEANVIEW
$553
BALCONY
$684
SUITE
$1,183
Save (per person) 269
From (per person) 474
View Trip
4 Day Ensenada Cruise with Royal Caribbean
Cruise

4 Days (3 Nights) San Diego to San Diego
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Dec 2026 to Apr 2027
Countries Visited: USA, Mexico
Exclusive Deal
INSIDE
$664
OCEANVIEW
$817
BALCONY
$918
SUITE
$1,186
Save (per person) 391
From (per person) 664
View Trip
5 Day Catalina & Ensenada Cruise with Royal Caribbean
Cruise

5 Days (4 Nights) San Diego to San Diego
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Feb 2027 to Mar 2027
Countries Visited: USA, Mexico
Exclusive Deal
INSIDE
$753
OCEANVIEW
$907
BALCONY
$1,039
SUITE
$1,275
Save (per person) 406
From (per person) 753
View Trip
4 Day Ensenada Cruise with Royal Caribbean
Cruise

4 Days (3 Nights) San Diego to San Diego
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Oct 2026 to Mar 2027
Countries Visited: USA, Mexico
Exclusive Deal
INSIDE
$664
OCEANVIEW
$817
BALCONY
$949
SUITE
$1,186
Save (per person) 370
From (per person) 664
View Trip
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