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Cruises From Santiago

Choose from 58 unique expeditions and cruises starting in Santiago, and travelling to Broome, Buenos Aires, Cape Town, Darwin, Fort Lauderdale and more. February is the most popular month to join a cruise from Santiago and you can select from 160 departures available from fourteen leading cruise lines.
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7 Days
58 Days
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End City
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58 Cruises (160 Cruise Departures)
20 Day Southern America & Panama Canal Cruise: Lima, Panama City & Cozumel with Azamara Cruises
Cruise
 (1)

20 Days (19 Nights) Santiago to Miami
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 10 March 2027
Countries Visited: Chile, Peru, Panama, Costa Rica (+3 more), Colombia, Mexico, USA
INSIDE
$7,355
OCEANVIEW
$8,177
BALCONY
$10,592
SUITE
$16,117
From (per person) 7,355
View Trip
15 Day South America Pathways: Chilean Fjords & Glaciers with Holland America
Cruise
 (2)

15 Days (14 Nights) Santiago to Buenos Aires
Cruise Line: Holland America
Ship: Oosterdam
Departure: 23 February 2027
Countries Visited: Chile, Argentina, Falkland Islands, Uruguay
Exclusive Deal
INSIDE
$3,457
OCEANVIEW
$3,853
BALCONY
$5,289
SUITE
$6,972
From (per person) 3,457
View Trip
16 Day South America Pathways: Chilean Fjords & Glaciers with Holland America
Cruise
 (2)

16 Days (15 Nights) Santiago to Buenos Aires
Cruise Line: Holland America
Ship: Oosterdam
Departure: 04 December 2026
Countries Visited: Chile, Argentina, Falkland Islands, Uruguay
Exclusive Deal
INSIDE
$3,552
OCEANVIEW
$3,938
BALCONY
$5,384
SUITE
$6,869
From (per person) 3,552
View Trip
20 Day Panama Canal & the Americas with Viking Cruises
Cruise
 (1)

20 Days (19 Nights) Santiago to New York
Operated By: Viking Cruises
Ships: Viking Octantis, Viking Polaris
Departures: Mar 2026 to Apr 2027
Countries Visited: Chile, Peru, Panama, Jamaica (+1 more), Bahamas
Companion Fly Free
INSIDE
-
OCEANVIEW
-
BALCONY
$18,811
SUITE
$25,671
Save (per person) 384
From (per person) 18,811
View Trip
18 Day Panama & Scenic South America with Viking Cruises
Cruise
 (1)

18 Days (17 Nights) Santiago to Fort Lauderdale
Operated By: Viking Cruises
Ships: Viking Octantis, Viking Polaris
Departures: Mar 2025 to Mar 2027
Countries Visited: Chile, Peru, Ecuador, Panama (+2 more), Mexico, USA
Companion Fly Free
INSIDE
-
OCEANVIEW
-
BALCONY
$15,871
SUITE
$22,731
Save (per person) 424
From (per person) 15,871
View Trip
13 Day Chilean Fjords & Scenic Shores with Viking Cruises
Cruise
 (1)

13 Days (12 Nights) Santiago to Buenos Aires
Operated By: Viking Cruises
Ships: Viking Octantis, Viking Polaris
Departures: Oct 2025 to Nov 2026
Countries Visited: Chile, Argentina
Companion Fly Free
INSIDE
-
OCEANVIEW
-
BALCONY
$12,735
SUITE
$17,635
Save (per person) 324
From (per person) 12,735
View Trip
18 Day South America & the Chilean Fjords with Viking Cruises
Cruise
 (4)

18 Days (17 Nights) Santiago to Buenos Aires
Operated By: Viking Cruises
Ship: Viking Jupiter
Departures: Mar 2025 to Feb 2027
Countries Visited: Chile, Argentina, Falkland Islands, Uruguay
Companion Fly Free
INSIDE
-
OCEANVIEW
-
BALCONY
$10,775
SUITE
$19,791
Save (per person) 278
From (per person) 10,775
View Trip
17 Day Inca & Panama Canal Discovery: Lima Overnight with Holland America
Cruise
 (2)

17 Days (16 Nights) Santiago to Fort Lauderdale
Cruise Line: Holland America
Ship: Oosterdam
Departure: 24 March 2027
Countries Visited: Chile, Peru, Ecuador, Panama (+2 more), Cayman Islands, USA
Exclusive Deal
INSIDE
$4,099
OCEANVIEW
$4,544
BALCONY
$5,584
SUITE
$7,861
From (per person) 4,099
View Trip
26 Day South American Discovery with Santiago Stopover & Galápagos Cruise with Globus
Tour + Cruise

26 Days Santiago to Guayaquil
Operated By: Globus
Departures: Jul 2025 to Nov 2026
Trip Styles: Coach, Cruise, Island Hopping, Wildlife, Scenic
Countries Visited: Chile, Brazil, Argentina, Peru (+2 more), Ecuador, Galapagos
Exclusive Deal
Save (per person) 552
From (per person) 19,611
View Trip
22 Day Puerto Williams to Buenos Aires with Silversea
Cruise

22 Days (21 Nights) Santiago to Buenos Aires
Cruise Line: Silversea
Ship: Silver Endeavour
Departure: 04 March 2027
Countries Visited: Chile, Antarctica, South Georgia Island, Falkland Islands (+1 more), Argentina
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$32,670
Save (per person) 5,130
From (per person) 32,670
View Trip
17 Day Edge Of The World Expedition with Regent Seven Seas
Cruise

17 Days (16 Nights) Santiago to Buenos Aires
Cruise Line: Regent Seven Seas
Ship: Seven Seas Splendor
Departure: 01 February 2026
Countries Visited: Chile, Argentina, Uruguay
Mutiple Deals Available
INSIDE
-
OCEANVIEW
-
BALCONY
$18,793
SUITE
$19,387
Save (per person) 6,967
From (per person) 18,793
View Trip
34 Day San Antonio To Southampton with Cunard
Cruise

34 Days (33 Nights) Santiago to London
Cruise Line: Cunard
Ship: Queen Anne
Departure: 28 February 2027
Countries Visited: Chile, Peru, Ecuador, Panama (+4 more), Aruba, USA, Portugal, England
Exclusive Deal
INSIDE
$9,317
OCEANVIEW
$13,871
BALCONY
$15,653
SUITE
$28,226
From (per person) 9,317
View Trip
19 Day Puerto Williams to Puerto Williams with Silversea
Cruise

19 Days (18 Nights) Santiago to Santiago
Cruise Line: Silversea
Ships: Silver Cloud, Silver Endeavour, Silver Wind
Departures: Feb 2025 to Feb 2026
Countries Visited: Chile, Falkland Islands, South Georgia Island, Antarctica
Mutiple Deals Available
INSIDE
-
OCEANVIEW
$25,047
BALCONY
$25,839
SUITE
$44,055
Save (per person) 5,068
From (per person) 25,047
View Trip
11 Day Puerto Williams to Ushuaia with Silversea
Cruise

11 Days (10 Nights) Santiago to Ushuaia
Cruise Line: Silversea
Ship: Silver Cloud
Departure: 09 March 2025
Countries Visited: Chile, Antarctica, Argentina
Port-to-Port
INSIDE
-
OCEANVIEW
$17,919
BALCONY
$21,384
SUITE
$29,799
From (per person) 17,919
View Trip
18 Day Antarctic Voyage with Chile with APT
Tour + Cruise

18 Days Santiago to Buenos Aires
Operated By: APT
Ship: Seabourn Venture
Departure: 14 February 2026
Trip Styles: Cruise, Scenic
Countries Visited: Chile, Argentina, Antarctica
Exclusive DealBusiness Class Included + Save
INSIDE
-
OCEANVIEW
-
BALCONY
$26,163
SUITE
$27,499
Save (per person) 2,632
From (per person) 26,163
View Trip
32 Day San Antonio To Southampton with Cunard
Cruise

32 Days (31 Nights) Santiago to London
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 25 February 2025
Countries Visited: Chile, Peru, Ecuador, Panama (+6 more), Aruba, Bahamas, USA, Bermuda, Portugal, England
Exclusive Deal
INSIDE
$7,237
OCEANVIEW
$8,910
BALCONY
$12,870
SUITE
$25,552
From (per person) 7,237
View Trip
24 Day Antarctica & Falklands - From Punta Arenas To Buenos Aires with HX Hurtigruten Expeditions
Cruise

24 Days (23 Nights) Santiago to Buenos Aires
Ship: MS Fram
Departure: 20 March 2026
Countries Visited: Chile, Antarctica, Falkland Islands, Argentina
Wave Offer
INSIDE
-
OCEANVIEW
$23,648
BALCONY
-
SUITE
$31,628
Save (per person) 5,862
From (per person) 23,648
View Trip
13 Day Chilean Fjords & The Glaciers of The Beagle Channel with Scenic
Cruise

13 Days (12 Nights) Santiago to Buenos Aires
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 04 November 2026
Countries Visited: Chile, Argentina
Super Earlybird
INSIDE
-
OCEANVIEW
-
BALCONY
$22,124
SUITE
$28,064
Save (per person) 6,691
From (per person) 22,124
View Trip
23 Day In-depth Antarctica, Falklands & South Georgia Expedition with HX Hurtigruten Expeditions
Cruise

23 Days (22 Nights) Santiago to Santiago
Ship: MS Fram
Departures: Nov 2025 to Jan 2027
Countries Visited: Chile, Falkland Islands, South Georgia Island, Antarctica
Wave Offer
INSIDE
-
OCEANVIEW
$28,186
BALCONY
-
SUITE
$37,488
Save (per person) 4,170
From (per person) 28,186
View Trip
7 Day King George Island to King George Island with Silversea
Cruise

7 Days (6 Nights) Santiago to Santiago
Cruise Line: Silversea
Ships: Silver Cloud, Silver Wind
Departures: Jan 2026 to Feb 2026
Countries Visited: Chile, Antarctica
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
$20,889
BALCONY
$26,532
SUITE
$36,531
Save (per person) 5,036
From (per person) 20,889
View Trip
20 Day San Antonio To Fort Lauderdale with Cunard
Cruise

20 Days (19 Nights) Santiago to Fort Lauderdale
Cruise Line: Cunard
Ship: Queen Anne
Departure: 28 February 2027
Countries Visited: Chile, Peru, Ecuador, Panama (+2 more), Aruba, USA
Exclusive Deal
INSIDE
$6,738
OCEANVIEW
$9,906
BALCONY
$11,193
SUITE
$19,806
From (per person) 6,738
View Trip
18 Day San Antonio To Fort Lauderdale with Cunard
Cruise

18 Days (17 Nights) Santiago to Fort Lauderdale
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 25 February 2025
Countries Visited: Chile, Peru, Ecuador, Panama (+3 more), Aruba, Bahamas, USA
Exclusive Deal
INSIDE
$5,252
OCEANVIEW
$6,192
BALCONY
$8,321
SUITE
-
From (per person) 5,252
View Trip
43 Day Grand World Voyage with Holland America
Cruise

43 Days (42 Nights) Santiago to Singapore
Cruise Line: Holland America
Ship: Volendam
Departure: 10 February 2026
Countries Visited: Chile, Easter Island, Pitcairn Islands, French Polynesia (+5 more), Tonga, New Zealand, Australia, Indonesia, Singapore
Exclusive Deal
INSIDE
$14,088
OCEANVIEW
$15,138
BALCONY
$28,146
SUITE
$52,649
From (per person) 14,088
View Trip
15 Day Cape Horn & Strait of Magellan with Princess
Cruise

15 Days (14 Nights) Santiago to Buenos Aires
Cruise Line: Princess
Ship: Sapphire Princess
Departure: 21 February 2025
Countries Visited: Chile, Argentina, Falkland Islands, Uruguay
Exclusive Deal
INSIDE
$4,426
OCEANVIEW
-
BALCONY
$7,139
SUITE
-
From (per person) 4,426
View Trip
30 Day Best of South America with Amazon and Galapagos Cruises with APT
Tour + Cruise

30 Days Santiago to Guayaquil
Operated By: APT
Ship: Delfin III
Departures: Aug 2025 to Sep 2025
Trip Styles: Coach, Cruise, River Cruise, Island Hopping, Wildlife, Scenic
Countries Visited: Chile, Argentina, Brazil, Peru (+2 more), Ecuador, Galapagos
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$40,052
Save (per person) 2,343
From (per person) 40,052
View Trip
22 Day Puerto Williams to Buenos Aires with Silversea
Cruise

22 Days (21 Nights) Santiago to Buenos Aires
Cruise Line: Silversea
Ship: Silver Endeavour
Departure: 10 March 2025
Countries Visited: Chile, Argentina, Falkland Islands, Antarctica
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$35,739
Save (per person) 2,861
From (per person) 35,739
View Trip
23 Day Puerto Williams to Valparaiso with Silversea
Cruise

23 Days (22 Nights) Santiago to Valparaiso
Cruise Line: Silversea
Ship: Silver Cloud
Departure: 09 March 2025
Countries Visited: Chile, Antarctica, Argentina
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
$25,542
BALCONY
$27,819
SUITE
$43,956
Save (per person) 5,058
From (per person) 25,542
View Trip
17 Day Cape Horn & Strait of Magellan with Princess
Cruise

17 Days (16 Nights) Santiago to Buenos Aires
Cruise Line: Princess
Ship: Sapphire Princess
Departure: 06 December 2025
Countries Visited: Chile, Argentina, Falkland Islands, Uruguay
Exclusive Deal
INSIDE
$5,061
OCEANVIEW
$5,185
BALCONY
$7,299
SUITE
-
From (per person) 5,061
View Trip
13 Day Puerto Williams to Puerto Williams with Silversea
Cruise

13 Days (12 Nights) Santiago to Santiago
Cruise Line: Silversea
Ship: Silver Endeavour
Departures: Feb 2025 to Jan 2026
Countries Visited: Chile, Antarctica
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$30,294
From (per person) 30,294
View Trip
29 Day Ultimate Journey: Patagonia, Argentina, Brazil & Antarctica - Cruise & Land Journey with Scenic
New ReleaseTour + Cruise

29 Days Santiago to Rio de Janeiro
Operated By: Scenic
Ships: Scenic Eclipse I
Departures: Feb 2026 to Jan 2027
Trip Styles: Coach, Cruise, Scenic
Countries Visited: Chile, Argentina, Antarctica, Brazil
Super Earlybird
INSIDE
-
OCEANVIEW
-
BALCONY
$61,143
SUITE
$66,722
Save (per person) 5,594
From (per person) 61,143
View Trip
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