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Cruises from Spain to Italy

Are you looking for a cruise from Spain to Italy? September is the most popular month to cruise between Spain and Italy and there are 296 departures available from seventeen of the world's leading cruise lines.
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146 Cruises (296 Cruise Departures)
8 Day Mediterranean with France & Italy with Princess
Cruise
 (2)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Sun Princess
Departures: Apr 2025 to Oct 2026
Countries Visited: Spain, Gibraltar, France, Italy
Exclusive Deal
INSIDE
$1,785
OCEANVIEW
$2,032
BALCONY
$2,398
SUITE
$2,726
From (per person) 1,785
View Trip
10 Day Greece, Malta & Turkey Cruise with Celebrity Cruises
Cruise

10 Days (9 Nights) Barcelona to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 30 August 2025
Countries Visited: Spain, Malta, Greece, Turkey (+1 more), Italy
Endless Summer Sale
INSIDE
$2,663
OCEANVIEW
$3,009
BALCONY
$4,019
SUITE
$8,930
Save (per person) 1,512
From (per person) 2,663
View Trip
13 Day Mediterranean Odyssey with Viking Cruises
Cruise
 (6)

13 Days (12 Nights) Barcelona to Venice
Operated By: Viking Cruises
Ships: Viking Jupiter, Viking Mars (+2 more), Viking Star, Viking Vesta
Departures: Mar 2026 to Jul 2027
Countries Visited: Spain, France, Italy, Greece (+1 more), Croatia
Companion Fly Free
INSIDE
-
OCEANVIEW
-
BALCONY
$10,971
SUITE
$16,361
Save (per person) 282
From (per person) 10,971
View Trip
27 Day Ramblas To Renaissance with Oceania Cruises
Cruise
 (1)

27 Days (26 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 09 December 2026
Countries Visited: Spain, Gibraltar, Morocco, Portugal (+3 more), France, Italy, Corsica
Exclusive Deal
INSIDE
$10,865
OCEANVIEW
$11,914
BALCONY
$18,082
SUITE
$25,141
Save (per person) 2,075
From (per person) 10,865
View Trip
13 Day Mediterranean Odyssey with Viking Cruises
Cruise
 (6)

13 Days (12 Nights) Barcelona to Venice
Operated By: Viking Cruises
Ships: Viking Neptune, Viking Saturn (+2 more), Viking Star, Viking Vela
Departures: Jun 2025 to Oct 2025
Countries Visited: Spain, France, Italy, Greece (+1 more), Croatia
Companion Fly Free
INSIDE
-
OCEANVIEW
-
BALCONY
$11,608
SUITE
$16,851
Save (per person) 260
From (per person) 11,608
View Trip
15 Day Iberia Celebration with Oceania Cruises
Cruise
 (1)

15 Days (14 Nights) Bilbao to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 30 August 2026
Countries Visited: Spain, Portugal, France, Italy
Exclusive Deal
INSIDE
$6,791
OCEANVIEW
$7,385
BALCONY
$11,147
SUITE
$15,355
Save (per person) 2,049
From (per person) 6,791
View Trip
11 Day Grand Mediterranean with Princess
Cruise
 (2)

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Sun Princess
Departure: 11 October 2025
Countries Visited: Spain, France, Italy, Montenegro (+1 more), Greece
Exclusive Deal
INSIDE
$2,642
OCEANVIEW
$3,321
BALCONY
$3,885
SUITE
$4,519
From (per person) 2,642
View Trip
12 Day Italy Cruise: Florence, Rome & Sorrento with Azamara Cruises
Cruise
 (1)

12 Days (11 Nights) Barcelona to Venice
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 13 September 2026
Countries Visited: Spain, France, Monaco, Italy (+3 more), Sicily, Montenegro, Slovenia
INSIDE
$4,743
OCEANVIEW
$5,535
BALCONY
$6,921
SUITE
$9,327
From (per person) 4,743
View Trip
11 Day Highlights of Spain, Morocco & Italy with Emerald Cruises
Cruise
 (3)

11 Days (10 Nights) Santa Cruz de Tenerife to Rome
Cruise Line: Emerald Cruises
Ship: Emerald Azzurra
Departure: 08 April 2026
Countries Visited: Spain, Morocco, Corsica, Italy
Super Earlybird
INSIDE
-
OCEANVIEW
$10,205
BALCONY
-
SUITE
$14,165
Save (per person) 2,590
From (per person) 10,205
View Trip
13 Day Best Of The Mediterranean Voyage with Azamara Cruises
Cruise
 (3)

13 Days (12 Nights) Barcelona to Venice
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 06 September 2025
Countries Visited: Spain, France, Monaco, Italy (+3 more), Montenegro, Croatia, Slovenia
INSIDE
$6,509
OCEANVIEW
$6,915
BALCONY
$9,499
SUITE
$12,261
From (per person) 6,509
View Trip
7 Day Mediterranean with France & Italy with Princess
Cruise
 (2)

7 Days (6 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Sun Princess
Departure: 19 March 2026
Countries Visited: Spain, Gibraltar, France, Italy
Exclusive Deal
INSIDE
$1,669
OCEANVIEW
$1,986
BALCONY
$2,139
SUITE
$2,319
From (per person) 1,669
View Trip
8 Day Mediterranean with France & Italy with Princess
Cruise
 (3)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Majestic Princess
Departure: 04 March 2025
Countries Visited: Spain, Gibraltar, Corsica, Italy
Exclusive Deal
INSIDE
$1,785
OCEANVIEW
-
BALCONY
$2,577
SUITE
$2,735
From (per person) 1,785
View Trip
8 Day Iconic Western Mediterranean with Viking Cruises
Cruise
 (5)

8 Days (7 Nights) Barcelona to Rome
Operated By: Viking Cruises
Ships: Viking Jupiter, Viking Mars (+8 more), Viking Mira, Viking Neptune, Viking Saturn, Viking Sea, Viking Sky, Viking Star, Viking Vela, Viking Vesta
Departures: Jul 2025 to Sep 2027
Countries Visited: Spain, France, Monaco, Italy
Companion Fly Free
INSIDE
-
OCEANVIEW
-
BALCONY
$5,287
SUITE
$7,247
Save (per person) 196
From (per person) 5,287
View Trip
12 Day Spain & Italy Cruise: Barcelona, Salerno & Rome with Azamara Cruises
Cruise
 (3)

12 Days (11 Nights) Barcelona to Rome
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 20 February 2027
Countries Visited: Spain, Sardinia, Tunisia, Malta (+2 more), Sicily, Italy
INSIDE
$4,407
OCEANVIEW
$5,120
BALCONY
$6,387
SUITE
$9,485
From (per person) 4,407
View Trip
3 Day Mediterranean with MSC Cruises
Cruise
 (1)

3 Days (2 Nights) Barcelona to Genoa
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 12 April 2025
Countries Visited: Spain, France, Italy
Holiday Breaks Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$720
SUITE
-
From (per person) 720
View Trip
28 Day Solar Eclipse Collectors' Voyage: Iberia & Italy with Holland America
Cruise
 (2)

28 Days (27 Nights) Barcelona to Rome
Cruise Line: Holland America
Ship: Oosterdam
Departure: 02 August 2026
Countries Visited: Spain, Morocco, Portugal, Corsica (+4 more), Italy, Montenegro, Greece, Sicily
Exclusive Deal
INSIDE
$7,224
OCEANVIEW
$8,115
BALCONY
-
SUITE
-
From (per person) 7,224
View Trip
8 Day Yachting Havens with Oceania Cruises
Cruise
 (3)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 05 May 2026
Countries Visited: Spain, France, Italy
Exclusive Deal
INSIDE
$3,152
OCEANVIEW
$3,444
BALCONY
$5,156
SUITE
$7,159
Save (per person) 2,188
From (per person) 3,152
View Trip
9 Day Spain & Italy Cruise: Barcelona, Portofino & Florence with Azamara Cruises
Cruise
 (1)

9 Days (8 Nights) Barcelona to Rome
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 09 April 2026
Countries Visited: Spain, France, Italy
INSIDE
$2,671
OCEANVIEW
$3,186
BALCONY
$4,097
SUITE
$5,691
From (per person) 2,671
View Trip
8 Day Costa Brave & Italy with Oceania Cruises
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 29 October 2026
Countries Visited: Spain, France, Corsica, Italy (+1 more), Sardinia
Exclusive Deal
INSIDE
$3,169
OCEANVIEW
$3,476
BALCONY
$5,129
SUITE
$7,080
Save (per person) 2,021
From (per person) 3,169
View Trip
8 Day Mediterranean with Total Solar Eclipse with Princess
Cruise
 (2)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Sun Princess
Departure: 08 August 2026
Countries Visited: Spain, Gibraltar, Italy
Exclusive Deal
INSIDE
$3,290
OCEANVIEW
$4,557
BALCONY
$5,765
SUITE
$6,398
From (per person) 3,290
View Trip
8 Day Southern France and the Italian Riviera by Sea – with Smithsonian Journeys with Ponant
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Ponant
Ship: Le Bougainville
Departure: 26 April 2025
Countries Visited: Spain, France, Italy
Exclusive Savings
INSIDE
-
OCEANVIEW
-
BALCONY
$9,761
SUITE
$14,818
Save (per person) 189
From (per person) 9,761
View Trip
11 Day Charmed Rivieras with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 21 April 2026
Countries Visited: Spain, France, Corsica, Sardinia (+1 more), Italy
Exclusive Deal
INSIDE
$4,585
OCEANVIEW
$5,084
BALCONY
$7,228
SUITE
$10,012
Save (per person) 2,275
From (per person) 4,585
View Trip
10 Day Western Mediterranean From Barcelona To Bologna with Norwegian Cruise Line
Cruise
 (1)

10 Days (9 Nights) Barcelona to Bologna
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Viva
Departures: Apr 2026 to Aug 2026
Countries Visited: Spain, France, Italy, Sicily (+3 more), Greece, Montenegro, Croatia
NCL's More at Sea
INSIDE
$4,498
OCEANVIEW
$5,277
BALCONY
$6,119
SUITE
$7,236
From (per person) 4,498
View Trip
4 Day Mediterranean with MSC Cruises
Cruise
 (1)

4 Days (3 Nights) Barcelona to Naples
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 23 April 2025
Countries Visited: Spain, France, Italy
Holiday Breaks Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$1,124
SUITE
-
From (per person) 1,124
View Trip
8 Day Mediterranean with France & Italy with Princess
Cruise
 (2)

8 Days (7 Nights) Barcelona to Naples
Cruise Line: Princess
Ship: Sun Princess
Departures: Jun 2025 to Sep 2025
Countries Visited: Spain, Gibraltar, France, Italy
Exclusive Deal
INSIDE
$1,686
OCEANVIEW
$2,111
BALCONY
$2,299
SUITE
$2,844
From (per person) 1,686
View Trip
9 Day Canary Islands And Madeira with MSC Cruises
Cruise
 (1)

9 Days (8 Nights) Santa Cruz De Tenerife to Rome
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 12 April 2026
Countries Visited: Spain, Morocco, Italy
Seasational Sale
INSIDE
$1,434
OCEANVIEW
$1,602
BALCONY
-
SUITE
-
From (per person) 1,434
View Trip
8 Day Mediterranean Cruise: Spain, France & Italy with Azamara Cruises
Cruise
 (3)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 28 November 2026
Countries Visited: Spain, France, Italy
INSIDE
$2,504
OCEANVIEW
$2,870
BALCONY
$3,682
SUITE
$5,751
From (per person) 2,504
View Trip
12 Day Western Mediterranean From Barcelona To Venice with Norwegian Cruise Line
Cruise
 (1)

12 Days (11 Nights) Barcelona to Venice
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Breakaway
Departures: May 2025 to Sep 2025
Countries Visited: Spain, France, Italy, Sicily (+3 more), Malta, Greece, Croatia
NCL's More at SeaExclusive Solo Offer
INSIDE
$3,174
OCEANVIEW
$4,551
BALCONY
$4,781
SUITE
$5,393
From (per person) 3,174
View Trip
15 Day Malta, Greece & Amalfi Coast Collectors' Voyage with Holland America
Cruise
 (2)

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Holland America
Ship: Oosterdam
Departure: 12 July 2026
Countries Visited: Spain, Malta, Greece, Turkey (+3 more), Montenegro, Sicily, Italy
Exclusive Deal
INSIDE
$3,633
OCEANVIEW
$4,227
BALCONY
$5,217
SUITE
$8,088
From (per person) 3,633
View Trip
8 Day Southern France and the Italian Riviera by Sea - with Smithsonian Journeys with Ponant
Cruise
 (2)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Ponant
Ship: Le Laperouse
Departure: 02 October 2025
Countries Visited: Spain, France, Italy
Exclusive Savings
INSIDE
-
OCEANVIEW
-
BALCONY
$10,810
SUITE
$16,504
Save (per person) 210
From (per person) 10,810
View Trip
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