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All Main River Cruises

The Main river flows through Germany from modern, densely populated Mainz to more traditional medieval Bavarian towns lined with lovely forests and small towns and dotted with hilltop castles and churches. Choose from 1,962 river cruises along the Main river travelling with the world's leading river cruise lines.
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167 River Cruises (1,962 River Cruise Departures)
8 Day Highlights of the Rhine and Main with APT
River Cruise

8 Days Amsterdam to Munich
Operated By: APT
Ship: APT Ostara
Departures: Oct 2025 to Nov 2025
Rivers: Rhine, Main
Countries Visited: Holland, Germany
Exclusive Savings
INSIDE
-
RIVER VIEW
$4,656
BALCONY
$6,388
SUITE
-
Save (per person) 1,058
From (per person) 4,656
View Trip
6 Day Festive Season in the Heart of Germany with Avalon River Cruises
River Cruise
 (2)

6 Days Frankfurt to Nuremberg
Operated By: Avalon River Cruises
Ships: Avalon Imagery II, Avalon Panorama
Departures: Dec 2025 to Dec 2026
Rivers: Main
Countries Visited: Germany
Exclusive Deal
INSIDE
-
RIVER VIEW
$4,324
BALCONY
$5,737
SUITE
$6,940
Save (per person) 439
From (per person) 4,324
View Trip
8 Day Festive Season in the Heart of Germany with Prague with Avalon River Cruises
River Cruise

8 Days Prague to Frankfurt
Operated By: Avalon River Cruises
Ships: Avalon Illumination, Avalon Imagery II, Avalon Panorama
Departures: Dec 2025 to Dec 2026
Rivers: Main
Countries Visited: Czech Republic, Germany
Exclusive Deal
INSIDE
-
RIVER VIEW
$5,301
BALCONY
$6,714
SUITE
$7,917
Save (per person) 449
From (per person) 5,301
View Trip
8 Day Classic Christmas Markets with Uniworld River Cruises
River Cruise

8 Days Frankfurt to Nuremberg
Ships: River Duchess, S.S. Elisabeth
Departures: Nov 2025 to Dec 2026
Rivers: Main
Countries Visited: Germany
Earlybird Saving
Save (per person) 857
From (per person) 6,061
View Trip
8 Day Festive Season in the Heart of Germany with Prague with Avalon River Cruises
River Cruise

8 Days Frankfurt to Prague
Operated By: Avalon River Cruises
Ships: Avalon Imagery II, Avalon Panorama
Departures: Dec 2025 to Dec 2026
Rivers: Main
Countries Visited: Germany, Czech Republic
Exclusive Deal
INSIDE
-
RIVER VIEW
$5,301
BALCONY
$6,714
SUITE
$7,917
Save (per person) 449
From (per person) 5,301
View Trip
6 Day Festive Season in the Heart of Germany with Avalon River Cruises
River Cruise

6 Days Nuremberg to Frankfurt
Operated By: Avalon River Cruises
Ships: Avalon Illumination, Avalon Imagery II, Avalon Panorama
Departures: Dec 2025 to Dec 2026
Rivers: Main
Countries Visited: Germany
Exclusive Deal
INSIDE
-
RIVER VIEW
$4,324
BALCONY
$5,737
SUITE
$6,940
Save (per person) 439
From (per person) 4,324
View Trip
8 Day Classic Christmas Markets with Uniworld River Cruises
River Cruise

8 Days Nuremberg to Frankfurt
Ships: River Duchess, S.S. Elisabeth
Departures: Dec 2025 to Dec 2026
Rivers: Main
Countries Visited: Germany
Earlybird Saving
Save (per person) 857
From (per person) 6,061
View Trip
9 Day German Grandeur with Avalon River Cruises
River Cruise
 (1)

9 Days Basel to Nuremberg
Operated By: Avalon River Cruises
Ship: Avalon Tranquility II
Departures: May 2025 to May 2026
Rivers: Rhine, Main
Countries Visited: Switzerland, France, Germany
Exclusive Deal
INSIDE
-
RIVER VIEW
$6,099
BALCONY
$8,248
SUITE
$10,171
Save (per person) 1,557
From (per person) 6,099
View Trip
11 Day German Grandeur with Munich with Avalon River Cruises
River Cruise
 (1)

11 Days Basel to Munich
Operated By: Avalon River Cruises
Ship: Avalon Tranquility II
Departures: May 2025 to May 2026
Rivers: Rhine, Main
Countries Visited: Switzerland, France, Germany
Exclusive Deal
INSIDE
-
RIVER VIEW
$7,373
BALCONY
$9,522
SUITE
$11,446
Save (per person) 1,570
From (per person) 7,373
View Trip
8 Day Three-Rivers Cruise with Amadeus River Cruises
New ReleaseRiver Cruise

8 Days Amsterdam to Nuremberg
Operated By: Amadeus River Cruises
Ship: Amadeus Riva
Departure: 06 May 2025
Rivers: Rhine, Main
Countries Visited: Holland, Germany
Exclusive Savings
INSIDE
-
RIVER VIEW
$4,540
BALCONY
$5,603
SUITE
$7,122
Save (per person) 93
From (per person) 4,540
View Trip
11 Day Rhine & Main Explorer with Viking River Cruises
New ReleaseRiver Cruise

11 Days Basel to Nuremberg
Operated By: Viking River Cruises
Ships: Viking Modi, Viking Skirnir
Departures: May 2025 to Nov 2027
Rivers: Rhine, Main
Countries Visited: Switzerland, France, Germany
Fly For Free
INSIDE
-
RIVER VIEW
$7,051
BALCONY
$8,227
SUITE
$12,931
Save (per person) 308
From (per person) 7,051
View Trip
10 Day Christmastime from Nuremberg to Basel with Avalon River Cruises
River Cruise

10 Days Nuremberg to Basel
Operated By: Avalon River Cruises
Ships: Avalon Illumination, Avalon Imagery II, Avalon Panorama
Departures: Dec 2025 to Dec 2026
Rivers: Main, Rhine
Countries Visited: Germany, France, Switzerland
Exclusive Deal
INSIDE
-
RIVER VIEW
$8,110
BALCONY
$10,655
SUITE
$12,818
Save (per person) 874
From (per person) 8,110
View Trip
12 Day Christmastime from Nuremberg to Basel with Prague with Avalon River Cruises
River Cruise

12 Days Prague to Basel
Operated By: Avalon River Cruises
Ship: Avalon Panorama
Departure: 06 December 2025
Rivers: Main, Rhine
Countries Visited: Czech Republic, Germany, France, Switzerland
Exclusive Savings
INSIDE
-
RIVER VIEW
$9,406
BALCONY
$11,799
SUITE
$13,942
Save (per person) 178
From (per person) 9,406
View Trip
12 Day Christmastime from Basel to Nuremberg with Prague with Avalon River Cruises
River Cruise

12 Days Basel to Prague
Operated By: Avalon River Cruises
Ships: Avalon Imagery II, Avalon Panorama
Departures: Nov 2025 to Dec 2025
Rivers: Rhine, Main
Countries Visited: Switzerland, France, Germany, Czech Republic
Exclusive Savings
INSIDE
-
RIVER VIEW
$9,406
BALCONY
$11,799
SUITE
$13,942
Save (per person) 178
From (per person) 9,406
View Trip
11 Day Rhine & Main Explorer with Viking River Cruises
New ReleaseRiver Cruise

11 Days Nuremberg to Basel
Operated By: Viking River Cruises
Ships: Viking Modi, Viking Skirnir
Departures: May 2025 to Nov 2027
Rivers: Main, Rhine
Countries Visited: Germany, France, Switzerland
Fly For Free
INSIDE
-
RIVER VIEW
$7,051
BALCONY
$7,933
SUITE
$12,931
Save (per person) 338
From (per person) 7,051
View Trip
10 Day Christmastime from Basel to Nuremberg with Avalon River Cruises
River Cruise

10 Days Basel to Nuremberg
Operated By: Avalon River Cruises
Ships: Avalon Imagery II, Avalon Panorama
Departures: Nov 2025 to Dec 2026
Rivers: Rhine, Main
Countries Visited: Switzerland, France, Germany
Exclusive Deal
INSIDE
-
RIVER VIEW
$8,332
BALCONY
$10,861
SUITE
$13,003
Save (per person) 652
From (per person) 8,332
View Trip
13 Day Christmastime from Budapest to Frankfurt with Avalon River Cruises
River Cruise

13 Days Budapest to Frankfurt
Operated By: Avalon River Cruises
Ships: Avalon Illumination, Avalon Passion, Avalon Panorama
Departures: Dec 2025 to Dec 2026
Rivers: Danube, Main
Countries Visited: Hungary, Austria, Germany
Exclusive Deal
INSIDE
-
RIVER VIEW
$10,751
BALCONY
$13,942
SUITE
$16,798
Save (per person) 499
From (per person) 10,751
View Trip
9 Day Christmastime on the Danube with Prague with Avalon River Cruises
River Cruise

9 Days Prague to Vienna
Operated By: Avalon River Cruises
Ships: Avalon Envision, Avalon Expression (+2 more), Avalon Impression, Avalon Tranquility II
Departures: Dec 2025 to Dec 2025
Rivers: Main, Danube
Countries Visited: Czech Republic, Germany, Austria
Exclusive Deal
INSIDE
-
RIVER VIEW
$5,659
BALCONY
$7,270
SUITE
$8,713
Save (per person) 852
From (per person) 5,659
View Trip
12 Day Christmastime from Frankfurt to Vienna with Avalon River Cruises
River Cruise

12 Days Frankfurt to Vienna
Operated By: Avalon River Cruises
Ships: Avalon Imagery II, Avalon Impression
Departure: 05 December 2025
Rivers: Main, Danube
Countries Visited: Germany, Austria
Exclusive Savings
INSIDE
-
RIVER VIEW
$9,941
BALCONY
$12,866
SUITE
-
Save (per person) 186
From (per person) 9,941
View Trip
13 Day Festive Season from Frankfurt to Budapest with Avalon River Cruises
River Cruise

13 Days Frankfurt to Budapest
Operated By: Avalon River Cruises
Ships: Avalon Imagery II, Avalon Panorama, Avalon Passion
Departures: Dec 2025 to Dec 2025
Rivers: Main, Danube
Countries Visited: Germany, Austria, Hungary
Exclusive Savings
INSIDE
-
RIVER VIEW
$10,751
BALCONY
$13,942
SUITE
$16,798
Save (per person) 201
From (per person) 10,751
View Trip
14 Day Europe's Rivers & Castles with Paris, Reims and Prague with AmaWaterways
New ReleaseRiver Cruise

14 Days Paris to Prague
Operated By: AmaWaterways
Ships: AmaCerto, AmaPrima
Departures: Apr 2025 to Oct 2025
Rivers: Moselle, Main
Countries Visited: France, Luxembourg, Germany, Czech Republic
Anniversary SaleSummer Triple Savings
INSIDE
-
RIVER VIEW
$8,409
BALCONY
$10,485
SUITE
$14,196
Save (per person) 1,581
From (per person) 8,409
View Trip
14 Day Europe's Rivers & Castles with Paris and Prague with AmaWaterways
New ReleaseRiver Cruise

14 Days Paris to Prague
Operated By: AmaWaterways
Ships: AmaCerto, AmaPrima
Departures: Apr 2025 to Oct 2026
Rivers: Moselle, Main
Countries Visited: France, Luxembourg, Germany, Czech Republic
Anniversary SaleSummer Triple Savings
INSIDE
-
RIVER VIEW
$8,409
BALCONY
$10,485
SUITE
$14,196
Save (per person) 1,590
From (per person) 8,409
View Trip
8 Day Europe's Rivers & Castles with AmaWaterways
New ReleaseRiver Cruise

8 Days Nuremberg to Luxembourg
Operated By: AmaWaterways
Ships: AmaCerto, AmaPrima
Departures: Apr 2025 to Sep 2026
Rivers: Main, Moselle
Countries Visited: Germany, Luxembourg
Anniversary SaleSummer Triple Savings
INSIDE
-
RIVER VIEW
$5,359
BALCONY
$7,583
SUITE
$11,295
Save (per person) 1,550
From (per person) 5,359
View Trip
14 Day Romantic Capitals: Prague to Paris with Tauck
New ReleaseRiver Cruise

14 Days Prague to Paris
Operated By: Tauck
Departures: Apr 2025 to Oct 2026
Rivers: Main, Moselle
Countries Visited: Czech Republic, Germany, Luxembourg, France
Exclusive Solo Offer
From (per person) 14,790
View Trip
8 Day Europe's Rivers & Castles (Wine Cruise) with AmaWaterways
New ReleaseRiver Cruise

8 Days Nuremberg to Luxembourg
Operated By: AmaWaterways
Ships: AmaPrima
Departures: Aug 2025 to Aug 2026
Rivers: Main, Moselle
Countries Visited: Germany, Luxembourg
Anniversary Sale
INSIDE
-
RIVER VIEW
$5,783
BALCONY
$7,859
SUITE
$11,571
Save (per person) 808
From (per person) 5,783
View Trip
12 Day Christmas on the Main & Moselle with Viking River Cruises
River Cruise

12 Days Prague to Paris
Operated By: Viking River Cruises
Ships: Viking Alsvin, Viking Idi
Departures: Dec 2026 to Dec 2027
Rivers: Main, Moselle
Countries Visited: Czech Republic, Germany, France
Fly For Free
INSIDE
-
RIVER VIEW
$8,031
BALCONY
$9,011
SUITE
$12,147
Save (per person) 188
From (per person) 8,031
View Trip
14 Day Romantic Capitals: Paris to Prague with Tauck
New ReleaseRiver Cruise

14 Days Paris to Prague
Operated By: Tauck
Departures: May 2025 to Oct 2026
Rivers: Moselle, Main
Countries Visited: France, Luxembourg, Germany, Czech Republic
Exclusive Solo Offer
From (per person) 14,840
View Trip
14 Day Europe's Rivers & Castles with Prague and Paris with AmaWaterways
New ReleaseRiver Cruise

14 Days Prague to Paris
Operated By: AmaWaterways
Ships: AmaCerto, AmaPrima
Departures: Apr 2025 to Aug 2026
Rivers: Main, Moselle
Countries Visited: Czech Republic, Germany, Luxembourg, France
Anniversary SaleSummer Triple Savings
INSIDE
-
RIVER VIEW
$8,861
BALCONY
$11,086
SUITE
$14,797
Save (per person) 1,586
From (per person) 8,861
View Trip
8 Day Europe's Rivers & Castles with AmaWaterways
New ReleaseRiver Cruise

8 Days Luxembourg to Nuremberg
Operated By: AmaWaterways
Ships: AmaCerto, AmaPrima
Departures: Apr 2025 to Oct 2026
Rivers: Moselle, Main
Countries Visited: Luxembourg, Germany
Anniversary SaleSummer Triple Savings
INSIDE
-
RIVER VIEW
$5,041
BALCONY
$7,117
SUITE
$10,828
Save (per person) 1,555
From (per person) 5,041
View Trip
14 Day Europe's Rivers & Castles with Prague, Reims and Paris (Wine Cruise) with AmaWaterways
New ReleaseRiver Cruise

14 Days Prague to Paris
Operated By: AmaWaterways
Ship: AmaPrima
Departure: 03 August 2025
Rivers: Main, Moselle
Countries Visited: Czech Republic, Germany, Luxembourg, France
Anniversary Sale
INSIDE
-
RIVER VIEW
$9,151
BALCONY
$11,227
SUITE
$14,939
Save (per person) 839
From (per person) 9,151
View Trip
14 Day Europe's Rivers & Castles with Prague, Reims and Paris with AmaWaterways
New ReleaseRiver Cruise

14 Days Prague to Paris
Operated By: AmaWaterways
Ships: AmaCerto, AmaPrima
Departures: Apr 2025 to Oct 2025
Rivers: Main, Moselle
Countries Visited: Czech Republic, Germany, Luxembourg, France
Anniversary Sale
INSIDE
-
RIVER VIEW
$9,151
BALCONY
$11,227
SUITE
$14,939
Save (per person) 839
From (per person) 9,151
View Trip
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