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Cruises from USA to Italy

Are you looking for a cruise from USA to Italy? April is the most popular month to cruise between USA and Italy and there are 25 departures available from ten of the world's leading cruise lines.
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15 Days
128 Days
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$1,300pp
$162,180pp
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24 Cruises (25 Cruise Departures)
15 Day Western Mediterranean Passage with Princess
Cruise
 (1)

15 Days (14 Nights) Fort Lauderdale to Rome
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 27 March 2026
Countries Visited: USA, Portugal, Gibraltar, Corsica (+1 more), Italy
Exclusive Deal
INSIDE
$1,421
OCEANVIEW
$2,104
BALCONY
$1,799
SUITE
$2,708
From (per person) 1,421
View Trip
22 Day Mediterranean Grand Adventure with Princess
Cruise
 (2)

22 Days (21 Nights) Fort Lauderdale to Rome
Cruise Line: Princess
Ship: Sun Princess
Departure: 22 March 2025
Countries Visited: USA, Spain, Gibraltar, France (+1 more), Italy
Exclusive Deal
INSIDE
$2,497
OCEANVIEW
$2,679
BALCONY
-
SUITE
$16,570
From (per person) 2,497
View Trip
21 Day Atlantic & Mediterranean Horizons with Viking Cruises
Cruise
 (7)

21 Days (20 Nights) Fort Lauderdale to Rome
Operated By: Viking Cruises
Ship: Viking Mars
Departures: Mar 2025 to Feb 2026
Countries Visited: USA, Sint Maarten, Portugal, Spain (+3 more), France, Monaco, Italy
Companion Fly Free
INSIDE
-
OCEANVIEW
-
BALCONY
$13,127
SUITE
$20,085
Save (per person) 386
From (per person) 13,127
View Trip
36 Day Crossing To Antiquity with Oceania Cruises
Cruise
 (1)

36 Days (35 Nights) Miami to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 27 March 2026
Countries Visited: USA, Bermuda, Portugal, Spain (+6 more), Morocco, Gibraltar, France, Corsica, Sardinia, Italy
Exclusive Deal
INSIDE
$13,580
OCEANVIEW
$14,937
BALCONY
$20,649
SUITE
$28,618
Save (per person) 2,090
From (per person) 13,580
View Trip
21 Day Western Mediterranean Grand Adventure with Princess
Cruise
 (2)

21 Days (20 Nights) Fort Lauderdale to Rome
Cruise Line: Princess
Ship: Sun Princess
Departure: 05 March 2026
Countries Visited: USA, Spain, Gibraltar, France (+1 more), Italy
Exclusive Deal
INSIDE
$3,169
OCEANVIEW
$3,414
BALCONY
$3,893
SUITE
$4,958
From (per person) 3,169
View Trip
16 Day Transatlantic Repositioning Cruise From New York to Rome with Norwegian Cruise Line
Cruise
 (1)

16 Days (15 Nights) New York to Rome
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Epic
Departure: 31 March 2025
Countries Visited: USA, Portugal, Spain, France (+1 more), Italy
NCL's More at Sea
INSIDE
$1,873
OCEANVIEW
-
BALCONY
$2,256
SUITE
$2,715
From (per person) 1,873
View Trip
20 Day Western Mediterranean & Adriatic Grand Adventure with Princess
Cruise
 (1)

20 Days (19 Nights) Fort Lauderdale to Rome
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 27 March 2026
Countries Visited: USA, Portugal, Gibraltar, Corsica (+3 more), Italy, Montenegro, Greece
Exclusive Deal
INSIDE
$2,265
OCEANVIEW
$3,601
BALCONY
$2,904
SUITE
$4,403
From (per person) 2,265
View Trip
128 Day Navigate The World with Regent Seven Seas
Cruise

128 Days (127 Nights) Miami to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Splendor
Departure: 11 January 2027
Countries Visited: USA, Mexico, Belize, Honduras (+33 more), Cayman Islands, Jamaica, Costa Rica, Colombia, Panama, Nicaragua, El Salvador, Guatemala, French Polynesia, American Samoa, Samoa, Fiji, Vanuatu, New Caledonia, Australia, Indonesia, Singapore, Malaysia, Thailand, Sri Lanka, Maldives, India, Oman, United Arab Emirates, Qatar, Saudi Arabia, Egypt, Jordan, Israel, Cyprus, Greece, Turkey, Italy
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$122,800
SUITE
$136,096
Save (per person) 39,380
From (per person) 122,800
View Trip
25 Day Atlantic Crossing & Spain's Southern Coast with Seabourn
Cruise

25 Days (24 Nights) Miami to Genoa
Cruise Line: Seabourn
Ship: Seabourn Quest
Departure: 26 April 2026
Countries Visited: USA, Portugal, Morocco, Gibraltar (+3 more), Spain, France, Italy
Exclusive Deal
INSIDE
-
OCEANVIEW
$13,882
BALCONY
$16,060
SUITE
$29,128
From (per person) 13,882
View Trip
16 Day Spanish Passage with Princess
Cruise

16 Days (15 Nights) Fort Lauderdale to Rome
Cruise Line: Princess
Ship: Emerald Princess
Departure: 24 March 2025
Countries Visited: USA, Portugal, Gibraltar, Spain (+2 more), Corsica, Italy
Exclusive Deal
INSIDE
$1,322
OCEANVIEW
$1,656
BALCONY
-
SUITE
$6,193
From (per person) 1,322
View Trip
16 Day Bermuda & Spain Transatlantic with Celebrity Cruises
Cruise

16 Days (15 Nights) Tampa to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Constellation
Departure: 12 April 2026
Countries Visited: USA, Bermuda, Portugal, Spain (+1 more), Italy
Endless Summer Sale
INSIDE
$1,906
OCEANVIEW
$2,204
BALCONY
$2,650
SUITE
$7,801
Save (per person) 940
From (per person) 1,906
View Trip
25 Day Miami to Rome with Silversea
Cruise

25 Days (24 Nights) Miami to Rome
Cruise Line: Silversea
Ship: Silver Nova
Departure: 31 May 2026
Countries Visited: USA, Portugal, Spain, France (+2 more), Monaco, Italy
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$22,473
From (per person) 22,473
View Trip
21 Day MSC Grand Voyages with MSC Cruises
Cruise

21 Days (20 Nights) New York to Amalfi
Cruise Line: MSC Cruises
Ship: MSC Meraviglia
Departure: 19 April 2026
Countries Visited: USA, Canada, Portugal, Spain (+5 more), Gibraltar, France, Tunisia, Sicily, Italy
Early Booking Offer
INSIDE
$2,959
OCEANVIEW
$3,524
BALCONY
$3,821
SUITE
$13,494
From (per person) 2,959
View Trip
15 Day Spain & Bermuda Transatlantic with Celebrity Cruises
Cruise

15 Days (14 Nights) Fort Lauderdale to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 20 April 2026
Countries Visited: USA, Bermuda, Portugal, Spain (+1 more), Italy
Endless Summer SaleSolo Offer + Onboard Credit
INSIDE
$2,585
OCEANVIEW
$2,957
BALCONY
$3,458
SUITE
$8,700
Save (per person) 1,424
From (per person) 2,585
View Trip
17 Day MSC Grand Voyages with MSC Cruises
Cruise

17 Days (16 Nights) Orlando to Genoa
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 18 April 2026
Countries Visited: USA, Saint Martin, Portugal, Spain (+2 more), France, Italy
Early Booking Offer
INSIDE
$2,184
OCEANVIEW
$2,629
BALCONY
$2,827
SUITE
$11,352
From (per person) 2,184
View Trip
16 Day MSC Grand Voyages with MSC Cruises
Cruise

16 Days (15 Nights) Miami to Rome
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 09 April 2026
Countries Visited: USA, Virgin Islands, Spain, France (+1 more), Italy
Early Booking OfferSeasational Sale
INSIDE
$2,567
OCEANVIEW
$2,854
BALCONY
$3,052
SUITE
$4,883
From (per person) 2,567
View Trip
17 Day Transoceanic Salute with Oceania Cruises
Cruise

17 Days (16 Nights) Miami to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 14 April 2026
Countries Visited: USA, Bahamas, Bermuda, Portugal (+2 more), Spain, Italy
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$5,742
SUITE
$10,097
Save (per person) 2,338
From (per person) 5,742
View Trip
16 Day Bermuda & Spain Transatlantic with Celebrity Cruises
Cruise

16 Days (15 Nights) Fort Lauderdale to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 20 April 2025
Countries Visited: USA, Bermuda, Gibraltar, Spain (+1 more), Italy
Endless Summer Sale
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$10,306
Save (per person) 6,543
From (per person) 10,306
View Trip
21 Day Atlantic Crossing: Miami To The Mediterranean with Seabourn
Cruise

21 Days (20 Nights) Miami to Rome
Cruise Line: Seabourn
Ship: Seabourn Encore
Departure: 28 April 2025
Countries Visited: USA, Portugal, Gibraltar, Corsica (+1 more), Italy
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$13,976
SUITE
-
From (per person) 13,976
View Trip
15 Day Italy, Spain, Azores Transatlantic with Royal Caribbean
Cruise

15 Days (14 Nights) New York to Rome
Cruise Line: Royal Caribbean
Ship: Odyssey of the Seas
Departure: 27 April 2025
Countries Visited: USA, Portugal, Spain, Italy
Exclusive DealExclusive Solo Offer
INSIDE
$2,232
OCEANVIEW
$2,798
BALCONY
$4,284
SUITE
-
Save (per person) 1,104
From (per person) 2,232
View Trip
22 Day Atlantic & Italian Stars with Oceania Cruises
Cruise

22 Days (21 Nights) Miami to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 07 April 2026
Countries Visited: USA, Bermuda, Portugal, Gibraltar (+5 more), Spain, France, Italy, Corsica, Sardinia
Exclusive Deal
INSIDE
$7,997
OCEANVIEW
$9,353
BALCONY
$10,551
SUITE
$15,214
Save (per person) 2,053
From (per person) 7,997
View Trip
19 Day MSC Grand Voyages with MSC Cruises
Cruise

19 Days (18 Nights) Orlando to Rome
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 18 April 2026
Countries Visited: USA, Saint Martin, Portugal, Spain (+2 more), France, Italy
Early Booking Offer
INSIDE
$2,488
OCEANVIEW
$2,993
BALCONY
$3,201
SUITE
-
From (per person) 2,488
View Trip
22 Day MSC Grand Voyages with MSC Cruises
Cruise

22 Days (21 Nights) New York to Florence
Cruise Line: MSC Cruises
Ship: MSC Meraviglia
Departure: 19 April 2026
Countries Visited: USA, Canada, Portugal, Spain (+5 more), Gibraltar, France, Tunisia, Sicily, Italy
Early Booking Offer
INSIDE
$3,171
OCEANVIEW
$3,705
BALCONY
$3,992
SUITE
$14,166
From (per person) 3,171
View Trip
17 Day Treasures Of The Atlantic with Regent Seven Seas
Cruise

17 Days (16 Nights) Miami to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Mariner
Departure: 15 April 2027
Countries Visited: USA, Bermuda, Spain, Corsica (+1 more), Italy
Exclusive DealUpgrade Your Horizon
INSIDE
-
OCEANVIEW
-
BALCONY
$15,095
SUITE
$15,610
Save (per person) 7,085
From (per person) 15,095
View Trip
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Cruises from USA to Italy

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