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Cruises from USA to Panama

Are you looking for a cruise from USA to Panama? December is the most popular month to cruise between USA and Panama and there are 28 departures available from eight of the world's leading cruise lines.
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21 Cruises (28 Cruise Departures)
11 Day Panama Potpourri with Oceania Cruises
Cruise
 (2)

11 Days (10 Nights) Miami to Panama City
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 23 March 2025
Countries Visited: USA, Mexico, Guatemala, Belize (+3 more), Honduras, Costa Rica, Panama
Exclusive Deal
INSIDE
$5,138
OCEANVIEW
$5,514
BALCONY
$7,732
SUITE
$10,266
Save 2,032
From 5,138
View Trip
11 Day Panama Potpourri with Oceania Cruises
Cruise
 (2)

11 Days (10 Nights) Miami to Panama City
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 08 February 2025
Countries Visited: USA, Mexico, Belize, Guatemala (+3 more), Honduras, Costa Rica, Panama
Exclusive Deal
INSIDE
$5,465
OCEANVIEW
$5,999
BALCONY
$8,207
SUITE
$10,741
Save 2,035
From 5,465
View Trip
19 Day Andes & South America with Princess
Cruise
 (3)

19 Days (18 Nights) Los Angeles to Santiago
Cruise Line: Princess
Ship: Majestic Princess
Departure: 01 December 2024
Countries Visited: USA, Mexico, Panama, Peru (+1 more), Chile
Exclusive Deal
INSIDE
$2,300
OCEANVIEW
-
BALCONY
$3,053
SUITE
$3,884
From 2,300
View Trip
11 Day Classic Panama Canal Passage with Viking Cruises
Cruise
 (4)

11 Days (10 Nights) Fort Lauderdale to Panama City
Cruise Line: Viking Cruises
Ship: Viking Mars
Departures: Oct 2024 to Dec 2025
Countries Visited: USA, Mexico, Belize, Honduras (+2 more), Costa Rica, Panama
Discover More Sale
INSIDE
-
OCEANVIEW
-
BALCONY
$5,440
SUITE
$8,410
Save 1,105
From 5,440
View Trip
11 Day Panama Canal Voyage with Azamara Cruises
Cruise
 (1)

11 Days (10 Nights) Miami to Panama City
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 03 December 2024
Countries Visited: USA, Aruba, Bonaire, Curacao (+2 more), Colombia, Panama
INSIDE
$4,273
OCEANVIEW
$4,465
BALCONY
$5,328
SUITE
$7,628
From 4,273
View Trip
10 Day Panama Canal - Miami with Norwegian Cruise Line
Cruise

10 Days (9 Nights) Miami to Panama City
Ship: Norwegian Gem
Departure: 02 December 2024
Countries Visited: USA, Dominican Republic, Curacao, Aruba (+1 more), Panama
Exclusive Solo Offer
INSIDE
$2,369
OCEANVIEW
$2,597
BALCONY
$3,775
SUITE
$3,929
From 2,369
View Trip
11 Day Palms & Panama Canal with Oceania Cruises
Cruise

11 Days (10 Nights) Tampa to Panama City
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 25 March 2026
Countries Visited: USA, Mexico, Belize, Honduras (+2 more), Costa Rica, Panama
Exclusive Deal
INSIDE
$5,026
OCEANVIEW
$5,482
BALCONY
$7,927
SUITE
$10,927
Save 2,034
From 5,026
View Trip
10 Day Panama Canal - Miami with Norwegian Cruise Line
Cruise

10 Days (9 Nights) Miami to Panama City
Ship: Norwegian Jade
Departure: 01 November 2025
Countries Visited: USA, Dominican Republic, Aruba, Colombia (+1 more), Panama
INSIDE
$2,667
OCEANVIEW
$3,126
BALCONY
$4,274
SUITE
$4,579
From 2,667
View Trip
12 Day Panama Canal Repositioning Cruise with Norwegian Cruise Line
Cruise

12 Days (11 Nights) Tampa to Panama City
Ship: Norwegian Jade
Departure: 29 January 2025
Countries Visited: USA, Mexico, Cayman Islands, Jamaica (+3 more), Colombia, Panama, Costa Rica
Exclusive Solo Offer
INSIDE
$2,803
OCEANVIEW
$3,063
BALCONY
$4,654
SUITE
$4,746
From 2,803
View Trip
12 Day Los Angeles to Panama City with Silversea
Cruise

12 Days (11 Nights) Los Angeles to Panama City
Cruise Line: Silversea
Ship: Silver Shadow
Departure: 09 May 2025
Countries Visited: USA, Mexico, Costa Rica, Panama
Port-to-PortExclusive Solo Offer
INSIDE
-
OCEANVIEW
$6,286
BALCONY
$7,474
SUITE
-
Save 814
From 6,286
View Trip
11 Day Panama Canal - Miami with Norwegian Cruise Line
Cruise

11 Days (10 Nights) Miami to Panama City
Ship: Norwegian Jade
Departure: 12 December 2025
Countries Visited: USA, Mexico, Belize, Honduras (+3 more), Cayman Islands, Colombia, Panama
INSIDE
$2,980
OCEANVIEW
$3,439
BALCONY
$4,662
SUITE
$5,045
From 2,980
View Trip
21 Day Andes & South America with Princess
Cruise

21 Days (20 Nights) Los Angeles to Santiago
Cruise Line: Princess
Ship: Sapphire Princess
Departure: 16 November 2025
Countries Visited: USA, Mexico, Costa Rica, Panama (+3 more), Ecuador, Peru, Chile
Exclusive Deal
INSIDE
$3,193
OCEANVIEW
$3,232
BALCONY
$4,539
SUITE
$6,044
From 3,193
View Trip
11 Day Panama Canal - Tampa with Norwegian Cruise Line
Cruise

11 Days (10 Nights) Tampa to Panama City
Ship: Norwegian Jade
Departure: 16 January 2026
Countries Visited: USA, Mexico, Belize, Honduras (+3 more), Cayman Islands, Colombia, Panama
INSIDE
$2,921
OCEANVIEW
$3,380
BALCONY
$4,603
SUITE
$4,985
From 2,921
View Trip
22 Day America's Historic Journey to Panama with Scenic
New ReleaseCruise

22 Days (21 Nights) New York to Panama City
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 05 October 2026
Countries Visited: USA, Bahamas, Colombia, Panama
Exclusive DealEarlybird Saving
INSIDE
-
OCEANVIEW
-
BALCONY
$19,939
SUITE
$25,126
Save 7,201
From 19,939
View Trip
16 Day Panama Canal - Miami with Norwegian Cruise Line
Cruise

16 Days (15 Nights) Miami to Panama City
Ship: Norwegian Jade
Departure: 04 January 2025
Countries Visited: USA, Dominican Republic, Puerto Rico, Virgin Islands (+7 more), Saint Lucia, Trinidad and Tobago, Grenada, Aruba, Colombia, Panama, Costa Rica
INSIDE
$3,338
OCEANVIEW
$3,766
BALCONY
$5,402
SUITE
$5,861
From 3,338
View Trip
18 Day Panama & Scenic South America with Viking Cruises
Cruise

18 Days (17 Nights) Fort Lauderdale to Santiago
Cruise Line: Viking Cruises
Ships: Viking Octantis, Viking Polaris
Departures: Oct 2024 to Oct 2025
Countries Visited: USA, Mexico, Panama, Ecuador (+2 more), Peru, Chile
Discover More Sale
INSIDE
-
OCEANVIEW
-
BALCONY
$10,885
SUITE
$15,340
Save 5,110
From 10,885
View Trip
13 Day Majestic Beaches & Canal Crossing with Regent Seven Seas
Cruise

13 Days (12 Nights) Miami to Panama City
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 03 January 2026
Countries Visited: USA, Cayman Islands, Jamaica, Bonaire (+5 more), Curacao, Aruba, Colombia, Costa Rica, Panama
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$11,690
SUITE
$12,363
Save 5,850
From 11,690
View Trip
13 Day Pacific Pathways with Oceania Cruises
Cruise

13 Days (12 Nights) Los Angeles to Colon
Cruise Line: Oceania Cruises
Ship: Oceania Regatta
Departure: 02 November 2025
Countries Visited: USA, Mexico, Guatemala, Nicaragua (+2 more), Costa Rica, Panama
Exclusive Deal
INSIDE
$5,979
OCEANVIEW
$6,514
BALCONY
$9,414
SUITE
$13,117
Save 2,041
From 5,979
View Trip
11 Day Vivid Western Caribbean with Oceania Cruises
Cruise

11 Days (10 Nights) Miami to Panama City
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 14 April 2026
Countries Visited: USA, Mexico, Belize, Honduras (+2 more), Costa Rica, Panama
Exclusive Deal
INSIDE
$5,028
OCEANVIEW
$5,483
BALCONY
$7,928
SUITE
$10,928
Save 2,032
From 5,028
View Trip
11 Day Panama Canal Repositioning Cruise with Norwegian Cruise Line
Cruise

11 Days (10 Nights) Galveston to Panama City
Ship: Norwegian Jade
Departure: 06 February 2026
Countries Visited: USA, Mexico, Belize, Honduras (+3 more), Cayman Islands, Colombia, Panama
INSIDE
$2,993
OCEANVIEW
$3,406
BALCONY
$4,706
SUITE
$5,134
From 2,993
View Trip
8 Day Fort Lauderdale to Panama City with Silversea
Cruise

8 Days (7 Nights) Fort Lauderdale to Panama City
Cruise Line: Silversea
Ship: Silver Shadow
Departure: 17 December 2024
Countries Visited: USA, Colombia, Panama
Port-to-PortExclusive Solo Offer
INSIDE
-
OCEANVIEW
$5,148
BALCONY
$6,633
SUITE
-
From 5,148
View Trip
Results: 21 results

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Routes

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