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Cruises from USA to Panama

Are you looking for a cruise from USA to Panama? November is the most popular month to cruise between USA and Panama and there are 20 departures available from seven of the world's leading cruise lines.
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23 Days
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15 Cruises (20 Cruise Departures)
11 Day Classic Panama Canal Passage with Viking Cruises
Cruise
 (7)

11 Days (10 Nights) Fort Lauderdale to Panama City
Operated By: Viking Cruises
Ship: Viking Mars
Departures: Oct 2025 to Dec 2026
Countries Visited: USA, Mexico, Belize, Honduras (+2 more), Costa Rica, Panama
Companion Fly Free
INSIDE
-
OCEANVIEW
-
BALCONY
$6,561
SUITE
$9,501
Save (per person) 144
From (per person) 6,561
View Trip
11 Day Passage To Panama with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Miami to Panama City
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 17 January 2026
Countries Visited: USA, Mexico, Belize, Guatemala (+3 more), Honduras, Costa Rica, Panama
Exclusive Deal
INSIDE
$4,451
OCEANVIEW
$4,884
BALCONY
$7,169
SUITE
$10,019
Save (per person) 2,259
From (per person) 4,451
View Trip
20 Day Panama Canal & the Americas with Viking Cruises
Cruise
 (1)

20 Days (19 Nights) New York to Santiago
Operated By: Viking Cruises
Ship: Viking Polaris
Departure: 25 October 2026
Countries Visited: USA, Bahamas, Jamaica, Panama (+2 more), Peru, Chile
Companion Fly Free
INSIDE
-
OCEANVIEW
-
BALCONY
$16,851
SUITE
$23,711
Save (per person) 344
From (per person) 16,851
View Trip
17 Day Inca & Panama Canal Discovery: Lima Overnight with Holland America
Cruise
 (2)

17 Days (16 Nights) Fort Lauderdale to Santiago
Cruise Line: Holland America
Ship: Oosterdam
Departure: 18 November 2026
Countries Visited: USA, Cayman Islands, Panama, Ecuador (+2 more), Peru, Chile
Exclusive Deal
INSIDE
$3,900
OCEANVIEW
$4,296
BALCONY
$5,286
SUITE
$7,563
From (per person) 3,900
View Trip
18 Day Panama & Scenic South America with Viking Cruises
Cruise
 (1)

18 Days (17 Nights) Fort Lauderdale to Santiago
Operated By: Viking Cruises
Ships: Viking Octantis, Viking Polaris
Departures: Oct 2025 to Nov 2026
Countries Visited: USA, Mexico, Panama, Ecuador (+2 more), Peru, Chile
Companion Fly Free
INSIDE
-
OCEANVIEW
-
BALCONY
$15,871
SUITE
$21,751
Save (per person) 324
From (per person) 15,871
View Trip
22 Day America's Historic Journey to Panama with Scenic
New ReleaseCruise

22 Days (21 Nights) New York to Panama City
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 05 October 2026
Countries Visited: USA, Bahamas, Colombia, Panama
Super Earlybird
INSIDE
-
OCEANVIEW
-
BALCONY
$30,825
SUITE
$39,428
Save (per person) 5,610
From (per person) 30,825
View Trip
11 Day Vivid Western Caribbean with Oceania Cruises
Cruise

11 Days (10 Nights) Miami to Panama City
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 14 April 2026
Countries Visited: USA, Mexico, Belize, Honduras (+2 more), Costa Rica, Panama
Exclusive Deal
INSIDE
$4,451
OCEANVIEW
$4,884
BALCONY
$7,169
SUITE
$9,877
Save (per person) 2,259
From (per person) 4,451
View Trip
21 Day Andes & South America with Princess
Cruise

21 Days (20 Nights) Los Angeles to Santiago
Cruise Line: Princess
Ship: Sapphire Princess
Departure: 16 November 2025
Countries Visited: USA, Mexico, Costa Rica, Panama (+3 more), Ecuador, Peru, Chile
Exclusive Deal
INSIDE
$4,617
OCEANVIEW
$4,789
BALCONY
$6,035
SUITE
$6,547
From (per person) 4,617
View Trip
15 Day Tropical Treasures with Regent Seven Seas
Cruise

15 Days (14 Nights) Miami to Panama City
Cruise Line: Regent Seven Seas
Ship: Seven Seas Splendor
Departure: 12 January 2027
Countries Visited: USA, Mexico, Belize, Honduras (+5 more), Cayman Islands, Jamaica, Costa Rica, Colombia, Panama
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$18,805
SUITE
$19,914
Save (per person) 7,105
From (per person) 18,805
View Trip
23 Day Atlantic Crossing & Panama Canal Passage with Seabourn
Cruise

23 Days (22 Nights) Lisbon to Panama City
Cruise Line: Seabourn
Ship: Seabourn Encore
Departure: 20 November 2025
Countries Visited: Portugal, Bermuda, USA, Bonaire (+3 more), Curacao, Colombia, Panama
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$13,098
SUITE
$24,384
From (per person) 13,098
View Trip
11 Day Palms & Panama Canal with Oceania Cruises
Cruise

11 Days (10 Nights) Tampa to Panama City
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 25 March 2026
Countries Visited: USA, Mexico, Belize, Honduras (+2 more), Costa Rica, Panama
Exclusive Deal
INSIDE
$4,684
OCEANVIEW
$5,288
BALCONY
$7,842
SUITE
$10,703
Save (per person) 2,026
From (per person) 4,684
View Trip
23 Day Palms To Andean Peaks with Oceania Cruises
Cruise

23 Days (22 Nights) Miami to Santiago
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 29 November 2025
Countries Visited: USA, Mexico, Belize, Guatemala (+6 more), Honduras, Costa Rica, Panama, Ecuador, Peru, Chile
Mutiple Deals Available
INSIDE
$5,089
OCEANVIEW
$6,348
BALCONY
$7,251
SUITE
$10,767
Save (per person) 5,421
From (per person) 5,089
View Trip
11 Day Caribbean & Panama Canal Passage with Seabourn
Cruise

11 Days (10 Nights) Miami to Panama City
Cruise Line: Seabourn
Ship: Seabourn Encore
Departure: 02 December 2025
Countries Visited: USA, Bonaire, Curacao, Colombia (+1 more), Panama
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$8,039
SUITE
$14,910
From (per person) 8,039
View Trip
13 Day Pacific Pathways with Oceania Cruises
Cruise

13 Days (12 Nights) Los Angeles to Colon
Cruise Line: Oceania Cruises
Ship: Oceania Regatta
Departure: 02 November 2025
Countries Visited: USA, Mexico, Guatemala, Nicaragua (+2 more), Costa Rica, Panama
Mutiple Deals Available
INSIDE
$3,083
OCEANVIEW
$3,460
BALCONY
$5,028
SUITE
$7,053
Save (per person) 4,537
From (per person) 3,083
View Trip
15 Day Exotic Coasts & Casco Viejo with Regent Seven Seas
Cruise

15 Days (14 Nights) Miami to Panama City
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 23 February 2027
Countries Visited: USA, Mexico, Belize, Honduras (+5 more), Cayman Islands, Jamaica, Costa Rica, Colombia, Panama
Exclusive DealUpgrade Your Horizon
INSIDE
-
OCEANVIEW
-
BALCONY
$13,330
SUITE
$13,617
Save (per person) 7,060
From (per person) 13,330
View Trip
Results: 15 results

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Countries

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Cities

Fort Lauderdale Los Angeles Miami New York Tampa

Routes

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Country Routes

Cruises from Chile to USA Cruises from Portugal to USA Cruises from USA to Chile Cruises from USA to Panama

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